Tibezonium Iodide
Structural Formula Vector Image
Title: Tibezonium Iodide
CAS Registry Number: 54663-47-7
CAS Name: N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide
Additional Names: diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide; 2-[b-(N-diethylamino)ethylthio]-4-(p-phenylthio)phenyl-3H-1,5-benzodiazepine methiodide; thiabenzazonium iodide
Manufacturers' Codes: Rec-15-0691
Trademarks: Antoral (Recordati)
Molecular Formula: C28H32IN3S2
Molecular Weight: 601.61
Percent Composition: C 55.90%, H 5.36%, I 21.09%, N 6.98%, S 10.66%
Literature References: 1,5-Benzodiazepine deriv with bactericidal activity. Prepn: D. Nardi et al., CH 555347 (1974 to Recordati), C.A. 82, 43480 (1975). Synthesis, physical characteristics, antibacterial activity: eidem, Experientia 31, 440 (1975); eidem, Farmaco Ed. Sci. 30, 248 (1975). Structure activity study: C. Greico et al., ibid. 32, 909 (1977). Antimicrobial activity: M. Veronese et al., Chemotherapy 23, 90 (1977). Toxicity study: D. Nardi et al., Experientia 31, 440 (1975).
Properties: Crystals from isopropanol, mp 162°. LD50 in mice, rats (mg/kg): 9000, >10000 orally; 42, 35 i.p. (Nardi).
Melting point: mp 162°
Toxicity data: LD50 in mice, rats (mg/kg): 9000, >10000 orally; 42, 35 i.p. (Nardi)
Therap-Cat: Antibacterial.
Keywords: Antiseptic/Disinfectant; Quaternary Ammonium Compounds.

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