Structural Formula Vector Image
Title: Clobuzarit
CAS Registry Number: 22494-47-9
CAS Name: 2-[[4¢-Chloro(1,1¢-biphenyl)-4-yl]methoxy]-2-methylpropanoic acid
Additional Names: 2-[[p-(p-chlorophenyl)benzyl]oxy]-2-methylpropionic acid
Manufacturers' Codes: ICI-55897
Trademarks: Clozic (ICI)
Molecular Formula: C17H17ClO3
Molecular Weight: 304.77
Percent Composition: C 67.00%, H 5.62%, Cl 11.63%, O 15.75%
Literature References: Analog of clofibrate. Prepn: T. Leigh, L. A. McArdle, GB 1140748; eidem, US 3549690 (1969, 1970 both to ICI). Pharmacological studies: M. E. J. Billingham, Br. J. Pharmacol. 72, 523 (1981); M. E. J. Billingham et al., ibid. 551. Effects on platelet function in atherosclerosis: J. R. O'Brien et al., Thromb. Haemostasis 40, 75 (1978). Comparative clinical evaluation with penicillamine: D. Y. Bulgen et al., Ann. Rheum. Dis. 38, 567 (1979); H. A. Bird et al., Clin. Exp. Rheumatol. 1, 93 (1983).
Properties: Crystals from benzene, mp 154-155°.
Melting point: mp 154-155°
Therap-Cat: Antirheumatic.
Status: This monograph has been retired and is no longer subject to revision or update.

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