美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Tipiracil HCl/Trifluridine	Tablet	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20 and 30	2017/11/02
Tipranavir	Capsule	II (Paddle)	50	0.05 M phosphate buffer pH 6.8	900	15, 30, 45 and 60	2007/12/03
Tivozanib HCl	Capsule	II (Paddle with sinker)	50	Tier I: 0.1 mM HCI with 0.5% (w/v) sodium dodecyl sulfate (SDS) (900 mL); Tier II: 0.1 mM HCI with pepsin (as per USP) (750 mL) for the first 10 minutes, followed by addition of 0.1 mM HCI with SDS (3% w/v) (150 mL) for the remainder of the dissolution	900	5, 10, 15, 20 and 30	2023/02/09
Tizanidine HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tizanidine HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tofacitinib Citrate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tofacitinib Citrate	Tablet (Extended Release)	II (Paddle) with option to use a sinker	50	Phosphate Buffer, pH 6.8	900	1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours	2016/07/28
Tolcapone	Tablet			Refer to USP			2013/05/09
Tolmetin Sodium	Tablet			Refer to USP			2026/03/25
Tolmetin Sodium	Capsule			Refer to USP			2026/03/25
Tolterodine Tartrate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tolterodine Tartrate	Capsule (Extended Release)	I (Basket)	100	Phosphate buffer (pH 6.8)	900	1, 3, 7 hours	2007/06/18
Tolvaptan	Tablet			Develop a dissolution method			2023/09/15
Topiramate	Capsule (Sprinkle)			Develop a dissolution method			2023/09/15
Topiramate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Topiramate [25, 50, 100, 150 mg and 200 mg]	Capsule (Extended Release)	I (Basket)	100	50 mM Tris buffer, pH 7.2	900	0.5, 1, 2, 4, 6 and 8 hours	2015/06/25
Topiramate [25, 50, 100 and 200 mg]	Capsule (Extended Release)	II (Paddle)	50	0.05 M Phosphate Buffer, pH 7.5	750	1, 2, 3, 4, 6 and 8 hours	2014/08/14
Topotecan HCl	Capsule	II (Paddle)	50	Acetate Buffer with 0.15% SDS, pH 4.5	500	5, 10, 20, 30 and 45	2009/04/27
Toremifene Citrate	Tablet	II (Paddle)	50	0.02 N HCl	1000	10, 20, 30 and 45	2004/02/20
Torsemide [40 mg]	Tablet	II (Paddle)	75	0.1 N HCl	900	1, 2, 3, 4, 6, 8, 10 and 12 hours	2022/07/07