美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Topiramate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Topiramate [25, 50, 100, 150 mg and 200 mg]	Capsule (Extended Release)	I (Basket)	100	50 mM Tris buffer, pH 7.2	900	0.5, 1, 2, 4, 6 and 8 hours	2015/06/25
Topiramate [25, 50, 100 and 200 mg]	Capsule (Extended Release)	II (Paddle)	50	0.05 M Phosphate Buffer, pH 7.5	750	1, 2, 3, 4, 6 and 8 hours	2014/08/14
Topotecan HCl	Capsule	II (Paddle)	50	Acetate Buffer with 0.15% SDS, pH 4.5	500	5, 10, 20, 30 and 45	2009/04/27
Toremifene Citrate	Tablet	II (Paddle)	50	0.02 N HCl	1000	10, 20, 30 and 45	2004/02/20
Torsemide [40 mg]	Tablet	II (Paddle)	75	0.1 N HCl	900	1, 2, 3, 4, 6, 8, 10 and 12 hours	2022/07/07
Torsemide [5 mg, 10 mg, 20 mg and 100 mg]	Tablet	II (Paddle)	50	0.1 N HCl	900	5, 10, 15 and 30	2004/02/20
Tovorafenib	Tablet	II (Paddle)	65	0.1 N HCl with 0.25% SDS	900	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Tovorafenib	For suspension	II (Paddle)	50	0.1 N HCl with 0.3% SDS	900	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Tramadol	Capsule (Extended Release)			Develop a dissolution method			2023/09/15
Tramadol HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tramadol HCl	Tablet (Extended Release)	I (Basket)	75	0.1 N HCl	900	2, 4, 8, 10 and 16 hours	2007/01/03
Trametinib Dimethyl Sulfoxide	Tablet	II (Paddle)	60	pH 4.5, 50 mM Sodium Acetate with 0.75% Sodium Lauryl Sulfate [SLS]	500	5, 10, 15, 20 and 30	2015/12/24
Trandolapril	Tablet			Develop a dissolution method			2023/09/15
Trandolapril/Verapamil HCl	Tablet (Extended Release)	II (Paddle)	50	Trandolapril: Develop a dissolution method; Verapamil: 0-1 hour Gastric Fluid w/o Pepsin pH=1.2, 1-8 hour Intestinal Fluid w/o Pancreatin	Verapamil: 900	Verapamil: 1, 2, 3.5, 5 and 8 hours	2023/09/15
Tranexamic Acid	Tablet			Develop a dissolution method			2023/09/15
Tranylcypromine Sulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Travoprost	Implant			Develop a method to characterize in vitro release			2026/01/28
Trazodone HCl	Tablet			Refer to USP			2023/05/18
Trazodone HCl	Tablet (Extended Release)			Develop a dissolution method			2023/09/15