Structural Formula Vector Image
Title: Synsorbs
CAS Registry Number: 83382-98-3
Literature References: Synthetic mimics of toxin receptor binding sites consisting of a trisaccharide covalently coupled via an 8-methoxycarbonyloctyl linker to Chromosorb® P (Celite Corp.) , a commercially available SiO2-based column matrix. Preparative methods for trisaccharides and linkers: R. U. Lemieux et al., J. Am. Chem. Soc. 97, 4076 (1975); D. D. Cox et al., Carbohydr. Res. 63, 139 (1978); P. J. Garegg, S. Oscarson, ibid. 136, 207 (1985).
Derivative Type: Synsorb Pk
CAS Registry Number: 192230-81-2
Literature References: Synthetic analog of the E. coli shigatoxin (verotoxin) receptor. Trisaccharide component is aGal(1® 4)bGal(1® 4)bGlc. Characterization of specificity: G. D. Armstrong et al., J. Infect. Dis. 164, 1160 (1991). Binding affinity: T. Takeda et al., Microbiol. Immunol. 43, 331 (1999). Clinical pharmacokinetics: G. D. Armstrong et al. J. Infect. Dis. 171, 1042 (1995). Review of clinical experience: idem et al., in Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains, J. B. Kaper, A. D. O'Brien, Eds. (American Society for Microbiology, Washington D.C., 1998) pp 374-384.
Derivative Type: Synsorb CD
Additional Names: Synsorb 90
Literature References: Synthetic analog of the Clostridium difficile toxin A receptor. Trisaccharide component is aGal(1® 3)bGal(1® 4)bGlc. Characterization of specificity: L. D. Heerze et al., J. Infect. Dis. 169, 1291 (1994); I. Castagliuolo et al., Gastroenterology 111, 433 (1996).
Therap-Cat: Synsorb Pk in the treatment of verotoxigenic E. coli gastroenteritis; Synsorb CD in the treatment of Clostridium difficile associated disease.

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