Structural Formula Vector Image
Title: Felbinac
CAS Registry Number: 5728-52-9
CAS Name: (1,1¢-Biphenyl)-4-acetic acid
Additional Names: 4-biphenylacetic acid; 4-carboxymethylbiphenyl; BPAA
Manufacturers' Codes: LY-61017; L-141; LJC-10141
Trademarks: Napageln (Lederle); Traxam (Lederle)
Molecular Formula: C14H12O2
Molecular Weight: 212.24
Percent Composition: C 79.23%, H 5.70%, O 15.08%
Literature References: One of the metabolites of fenbufen, q.v. Prepn: E. Schwenk, D. Papa, J. Org. Chem. 11, 798 (1946). Improved prepn: G. R. Malone, A. I. Meyers, ibid. 39, 618 (1974). Pharmacology: A. E. Sloboda, A. C. Osterberg, Inflammation 1, 415 (1976). Mode of action study in ocular inflammation: E. L. Tolman et al., Invest. Ophthalmol. 15, 1005 (1976). HPLC determn in serum: J. S. Fleitman et al., J. Chromatogr. 228, 372 (1982).
Properties: White needles from ethyl ether, mp 164-165°. LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg).
Melting point: mp 164-165°
Toxicity data: LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)
Derivative Type: Ethyl ester
CAS Registry Number: 14062-23-8
Manufacturers' Codes: LM-001
Trademarks: Daitec (Lederle)
Molecular Formula: C16H16O2
Molecular Weight: 240.30
Percent Composition: C 79.97%, H 6.71%, O 13.32%
Therap-Cat: Anti-inflammatory, analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.

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