Structural Formula Vector Image
Title: Nicomol
CAS Registry Number: 27959-26-8
CAS Name: 3-Pyridinecarboxylic acid (2-hydroxy-1,3-cyclohexanediylidene)tetrakis(methylene) ester
Additional Names: nicotinic acid 1,1,3,3-tetraester with 2-hydroxy-1,1,3,3-cyclohexanetetramethanol; 2-hydroxycyclohexane-1,1,3,3-tetramethanol tetraester with nicotinic acid; tetranicotinic acid 2-hydroxycyclohexa-1,1,3,3-tetramethyl ester; 2,2,6,6-tetrakis(hydroxymethyl)-1-cyclohexanol 2,2,6,6-tetranicotinate; nicotinic acid 2-hydroxy-1,3-cyclohexanediylidenetetrakismethylene ester; 2,2,6,6-tetrakis(nicotinoyloxymethyl)cyclohexanol
Trademarks: K-31 (Kyorin); Cholexamin (Kyorin)
Molecular Formula: C34H32N4O9
Molecular Weight: 640.64
Percent Composition: C 63.74%, H 5.03%, N 8.75%, O 22.48%
Literature References: Prepn: BE 658422 corresp to Irikura et al., US 3299077 (1965 and 1967 to Kyorin). Hypocholesterolemic action studies: Aso et al., J. Atheroscler. Res. 10, 391 (1969). Acute toxicity data: T. Sugawara et al., Oyo Yakuri 14, 741 (1977), C.A. 88, 131005v (1977). Review: Jpn. Med. Gaz. 8(8), 9 (1971).
Properties: Crystals from dilute acetic acid, mp 177-180°. Practically odorless and tasteless. One gram is sol in 3 ml 1N HCl and 10 ml chloroform. Slightly sol in water, ethanol and ether. LD50 in mice, male and female rats (g/kg): >10, 15, <10 orally; >5, >2.5, >2.5 i.p. (Sugawara).
Melting point: mp 177-180°
Toxicity data: LD50 in mice, male and female rats (g/kg): >10, 15, <10 orally; >5, >2.5, >2.5 i.p. (Sugawara)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Nicotinic Acid Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.

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