Structural Formula Vector Image
Title: Ethaverine
CAS Registry Number: 486-47-5
CAS Name: 1-[(3,4-Diethoxyphenyl)methyl]-6,7-diethoxyisoquinoline
Additional Names: 6,7-diethoxy-1-(3,4-diethoxybenzyl)isoquinoline; ethylpapaverine
Trademarks: Dyscural
Molecular Formula: C24H29NO4
Molecular Weight: 395.49
Percent Composition: C 72.89%, H 7.39%, N 3.54%, O 16.18%
Literature References: Tetraethyl homolog of papaverine. Synthesis: Wolf, US 1962224 (1934).
Properties: Crystals from alcohol + ether, mp 99-101°. Insol in water. Readily sol in hot alc; slightly in ether and chloroform.
Melting point: mp 99-101°
Derivative Type: Hydrochloride
CAS Registry Number: 985-13-7
Trademarks: Barbonin (Knoll); Circubid (W. F. Merchant); Diquinol (Parke-Davis); Ethabid (Meyer); Isovex; Laverin (Lemmon); Perparin (Chemopuro); Perperine
Molecular Formula: C24H29NO4.HCl
Molecular Weight: 431.95
Percent Composition: C 66.73%, H 7.00%, N 3.24%, O 14.82%, Cl 8.21%
Literature References: Prepn of stable solns: Hereld, US 2971888 (1961).
Properties: Crystals from abs alc, mp 186-188° (dec). One gram dissolves in about 40 ml water. pH of 1% soln 3.6; of 0.1% soln 4.6.
Melting point: mp 186-188° (dec)
Derivative Type: Acid oxalate
Molecular Formula: C24H29NO4.(COOH)2
Molecular Weight: 485.53
Percent Composition: C 64.32%, H 6.44%, N 2.88%, O 26.36%
Properties: Crystals from alc, soluble in hot water.
Derivative Type: Salt with 7-iodo-8-hydroxyquinoline-5-sulfonic acid
Literature References: Prepn: HU 106906 (1931); v. Issekutz et al., Arch. Exp. Pathol. Pharmakol. 164, 158 (1932).
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.

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