Structural Formula Vector Image
Title: Ectylurea
CAS Registry Number: 95-04-5
CAS Name: (Z)-N-(Aminocarbonyl)-2-ethyl-2-butenamide
Additional Names: (2-ethylcrotonoyl)urea; (a-ethylcrotonyl)urea; (a-ethylcrotonyl)carbamide
Trademarks: Astyn; Ektyl; Levanil (Upjohn); Nostal (Ames); Nostyn (Ames); Cronil (Farmigea); Neuroprocin; Pacetyn
Molecular Formula: C7H12N2O2
Molecular Weight: 156.18
Percent Composition: C 53.83%, H 7.74%, N 17.94%, O 20.49%
Literature References: Prepd by treating (2-bromo-2-ethylbutyryl)urea with dil boiling NaOH: Newbery, J. Chem. Soc. 127, 295 (1925). Prepn from carbromal and isopropanol by refluxing with silver oxide: Fancher, US 2854379, US 2931832 (1958, 1960 to Miles Labs.). Pharmacology and toxicity: M. H. Pindell et al., Fed. Proc. 12, 357 (1953).
Properties: Needles from benzene, mp 198°, also reported as mp 191-193° (lower melting form, mp 158°). Very slightly sol in ether, hot alcohol, other organic solvents. Sol in concd aq solns of alkalies and acids. LD50 in rats (mg/kg): 2500 orally; 900 i.p. (Pindell).
Melting point: mp 198°, also reported as mp 191-193° (lower melting form, mp 158°)
Toxicity data: LD50 in rats (mg/kg): 2500 orally; 900 i.p. (Pindell)
Therap-Cat: Sedative; hypnotic.
Keywords: Sedative/Hypnotic; Acylic Ureides.
Status: This monograph has been retired and is no longer subject to revision or update.

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