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Title: Abatacept
CAS Registry Number: 332348-12-6
Additional Names: 1-25-Oncostatin M (human precursor) fusion protein with CTLA-4 (antigen)(human) fusion protein with immunoglobulin G1 (human heavy chain fragment); CTLA-4Ig
Manufacturers' Codes: BMS-188667
Trademarks: Orencia (BMS)
Literature References: Selective costimulation modulator that inhibits T cell activation via the CD28/B7 receptor pathway. Recombinant chimeric fusion protein composed of the extracellular domain of human cytotoxic lymphocyte-associated antigen 4 (CTLA-4) fused to the heavy constant region of human IgG. Prepn: P. S. Linsley et al., J. Exp. Med. 174, 561 (1991); eidem, WO 9300431; eidem, US 5434131 (1993, 1995 both to Bristol-Myers Squibb). CE and HPLC analysis: K. F. Greve et al., J. Chromatogr. A 723, 273 (1996). Pharmacokinetics: N. R. Srinivas et al., J. Pharm. Sci. 85, 1 (1996). Clinical evaluation in psoriasis: J. R. Abrams et al., J. Clin. Invest. 103, 1243 (1999); in rheumatoid arthritis (RA): J. M. Kremer et al., Arthritis Rheum. 52, 2263 (2005); M. C. Genovese et al., N. Engl. J. Med. 353, 1114 (2005). Review of pharmacology: N. Najafian, M. H. Sayegh, Expert Opin. Invest. Drugs 9, 2147-2157 (2000); of mechanism of action and clinical development in RA: G. G. Teng et al., Expert Opin. Biol. Ther. 5, 1245-1254 (2005).
Therap-Cat: Immunosuppressant; antipsoriatic.
Keywords: Immunosuppressant; Antipsoriatic.

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