4-Hydroxyisophthalic Acid
Structural Formula Vector Image
Title: 4-Hydroxyisophthalic Acid
CAS Registry Number: 636-46-4
CAS Name: 4-Hydroxy-1,3-benzenedicarboxylic acid
Molecular Formula: C8H6O5
Molecular Weight: 182.13
Percent Composition: C 52.76%, H 3.32%, O 43.92%
Literature References: Prepd by high pressure carbonation of potassium phenate (Kolbe-Schmitt reaction): Baine et al., J. Org. Chem. 19, 510 (1954) or by boiling salicylic acid with carbon tetrachloride in alkaline medium in the presence of Cu powder: DE 258887 (1913 to Zeltner & Landau); Chem. Zentralbl. 1913, I, 1641; Frdl. 11, 210. Major constituent of the brown dust residue from sublimation of salicylic acid: Hunt et al., Chem. Ind. (London) 1955, 417.
Properties: Branched needles from water, platelets from dil alc. Dec 314-315°. One gram dissolves in 3 liters of water at 24°, in 160 ml at 100°. Freely sol in alcohol, ether.
Derivative Type: Dimethyl ester
Properties: Crystals, mp 97.5°.
Melting point: mp 97.5°
Derivative Type: Diethyl ester
Properties: Crystals, mp 54-55°.
Melting point: mp 54-55°
NOTE: 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin: Chesher et al., Nature 175, 206 (1955).

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