Structural Formula Vector Image
Title: Oxotremorine
CAS Registry Number: 70-22-4
CAS Name: 1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone
Additional Names: 1-(2-oxo-1-pyrrolidinyl)-4-(1-pyrrolidinyl)-2-butyne
Molecular Formula: C12H18N2O
Molecular Weight: 206.28
Percent Composition: C 69.87%, H 8.80%, N 13.58%, O 7.76%
Literature References: Active metabolite of tremorine, q.v.: Cho et al., Biochem. Biophys. Res. Commun. 5, 276 (1961). Synthesis: Bebbington, Shakeshaft, J. Med. Chem. 8, 274 (1965); Nau, US 3444185 (1969 to Soc. Civile Auguil). Cholinergic agent, used experimentally as convulsant in study of parkinsonism: Cho et al., Proc. 2nd Int. Pharmacol. Meet. 2, 75 (1964).
Properties: Pale yellow liquid. bp0.6 150-155°; bp0.1 124°. nD25 1.5156.
Boiling point: bp0.6 150-155°; bp0.1 124°
Index of refraction: nD25 1.5156
Derivative Type: Picrolonate
Molecular Formula: C22H26N6O6
Molecular Weight: 470.48
Percent Composition: C 56.16%, H 5.57%, N 17.86%, O 20.40%
Properties: Crystals from acetone, mp 157-159°.
Melting point: mp 157-159°
Use: Pharmacological tool.

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