2-Aminothiazole
Structural Formula Vector Image
Title: 2-Aminothiazole
CAS Registry Number: 96-50-4
CAS Name: 2-Thiazolamine
Trademarks: Abadol (Specia); Basedol
Molecular Formula: C3H4N2S
Molecular Weight: 100.14
Percent Composition: C 35.98%, H 4.03%, N 27.97%, S 32.02%
Literature References: Prepn from vinyl acetate: Christiansen, US 2242237 (1941 to Squibb); Kyrides, US 2330223 (1943 to Monsanto); cf. Skrimshire, GB 540032 (1941 to B.D.H.). Prepd also by condensing tribromoparaldehyde with thiourea: Leitch, Brickman, US 2230962 (1941); US 2339083 (1944 to Mallinckrodt). Prepn from paraldehyde and thiourea: Erlenmeyer et al., Helv. Chim. Acta 38, 1293 (1955). Toxicology: W. B. Deichmann et al., J. Ind. Hyg. Toxicol. 30, 71 (1948).
Properties: Crystals from benzene + petr ether, mp 93°. Distills at 3 mm without decompn. Sol in hot water. Slightly sol in cold water, alc, ether. Freely sol in dil HCl and in 20% H2SO4. LD50 orally in rats: 0.48 g/kg (Deichmann).
Melting point: mp 93°
Toxicity data: LD50 orally in rats: 0.48 g/kg (Deichmann)
 
Derivative Type: Hydrochloride monohydrate
Molecular Formula: C3H4N2S.HCl.H2O
Molecular Weight: 154.62
Percent Composition: C 23.30%, H 4.56%, N 18.12%, S 20.74%, Cl 22.93%, O 10.35%
Properties: Needles, freely sol in water. Also used as the acid tartrate. Crystals, sol in water.
 
Therap-Cat: Thyroid inhibitor.
Keywords: Antihyperthyroid.

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