Methcathinone
Structural Formula Vector Image
Title: Methcathinone
CAS Registry Number: 5650-44-2
CAS Name: 2-(Methylamino)-1-phenyl-1-propanone
Additional Names: a-methylaminopropiophenone; monomethylpropion; ephedrone; Jeff; mulka; cat; cosmos; Jee cocktail
Molecular Formula: C10H13NO
Molecular Weight: 163.22
Percent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%
Literature References: Oxidation product of ephedrine possessing amphetamine-like central stimulant properties. Prepn: J. F. Hyde et al., J. Am. Chem. Soc. 50, 2287 (1928); K. Y. Zhingel et al., J. Forensic Sci. 36, 915 (1991). Prepn of enantiomers and chromatographic analysis: J. DeRuiter et al., J. Chromatogr. Sci. 32, 552 (1994). Comparative pharmacology: R. Young, R. A. Glennon, Pharmacol. Biochem. Behav. 45, 229 (1993). Pharmacology of enantiomers: R. A. Glennon et al., ibid. 50, 601 (1995). Absorption and metabolism: S. L. Markantonis et al., J. Pharm. Pharmacol. 38, 515 (1986). GLC/MS determn in urine: eidem, Chim. Chron. 14, 211 (1985). Impact on public health: T. S. Emerson, J. E. Cisek, Ann. Emerg. Med. 22, 1897 (1993).
 
Derivative Type: Hydrochloride
CAS Registry Number: 49656-78-2
Molecular Formula: C10H13NO.HCl
Molecular Weight: 199.68
Percent Composition: C 60.15%, H 7.07%, N 7.01%, O 8.01%, Cl 17.75%
Properties: Crystals from alcohol-acetone, mp 176-177°.
Melting point: mp 176-177°
 
Derivative Type: l-Form hydrochloride
Molecular Formula: C10H13NO.HCl
Molecular Weight: 199.68
Percent Composition: C 60.15%, H 7.07%, N 7.01%, O 8.01%, Cl 17.75%
Literature References: Prepn: Y. J. L'Italien, M. C. Rebstock, US 2802865 (1957 to Parke, Davis).
Properties: Crystals from ethanol-ether or chloroform-petr ether, mp 182-183°. Pungent taste. [a]D25 -53° (c = 1 in water). Sol in water. LD50 in mice, rats (mg/kg): 106, 90 iv; 233, 86 sc; 342, 99 orally (Emerson).
Melting point: mp 182-183°
Optical Rotation: [a]D25 -53° (c = 1 in water)
Toxicity data: LD50 in mice, rats (mg/kg): 106, 90 iv; 233, 86 sc; 342, 99 orally (Emerson)
 
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.11.

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