Perfluorooctyl bromide [423-55-2].
» Perflubron contains not less than 98.0 and not more than 100.0 percent of C8BrF17.
Packaging and storage Preserve in tight, light-resistant containers.
A: Record the IR absorption spectrum, using a gas cell. The spectrum so obtained exhibits maxima only at the same wavelengths as that of a similar preparation of USP Perflubron RS.
Specific gravity 841: between 1.922 and 1.925.
Chromatographic system (see Chromatography 621)The gas chromatograph is equipped with a split injection port with a split ratio, range of 1:45 to 1:100, a flame-ionization detector, and a 0.25-mm × 60-m column coated with a 1-µm film of phase G2. Hydrogen is used as the carrier gas. The chromatograph is programmed to maintain the column temperature at 35 for 7 minutes, then to increase the temperature at a rate of 20 per minute to 185, and held at this temperature for 4.5 minutes. The injection port is maintained between 200 and 220 and the detector at a temperature above 200.
Procedure Inject a volume (about 0.2 µL) of Perflubron into the chromatograph, record the chromatogram, and measure the areas of the peak responses. Calculate the percentage of each individual impurity in the portion of Perflubron taken by the formula:
100(ri / rs)in which ri is the peak response of the individual impurity, and rs is the sum of the responses of all the peaks: not more than 0.20% of any individual impurity is found.
Nonvolatile residue Transfer 75 g of Perflubron to a tared evaporating dish, evaporate to dryness, and dry the residue at 105 for 1 hour: the weight of the residue so obtained does not exceed 1.5 mg (0.002%).
Chromatographic system Proceed as directed in the test for Chromatographic purity.
Procedure Inject about 0.2 µL of Perflubron into the chromatograph, record the chromatograms, and measure the areas of the peak responses. Calculate the percentage of C8BrF17 in the portion of Perflubron taken by the formula:
100(rU / rs)in which rU is the peak response for perflubron obtained from the test specimen, and rs is the sum of the responses of all of the peaks.
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USP32NF27 Page 3256