美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Atorvastatin Calcium	Suspension	II (Paddle)	75	0.05 M Phosphate Buffer, pH 6.8	900	5, 10, 15 and 30	2024/05/31
Atorvastatin Calcium/Ezetimibe	Tablet	II (Paddle), with option to use a sinker for 20/10 mg strength	75	Phosphate buffer, pH 6.8 with 0.2% w/v Tween 80	900	5, 10, 15, 20, 30 and 45	2014/05/15
Atovaquone	Oral Suspension			Develop a dissolution method			2009/07/21
Atovaquone	Tablet	II (Paddle)	50	40% isopropanol buffered to pH 8.0 with potassium dihydrogen phosphate	900	10, 20, 30, 45, 60 and 90	2007/06/18
Atovaquone/Proguanil HCl	Tablet	II (Paddle) with PEAK vessels	50	40% isopropranol buffered to pH 8.0 with potassium dihydrogen phosphate	900	15, 30, 45 and 60	2006/08/17
Atrasentan Hydrochloride	Tablet	II (Paddle)	50	50 mM Sodium Phosphate Buffer, pH 4.5	500	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Atropine Sulfate/ Diphenoxylate HCl	Tablet			Develop dissolution method(s) to characterize the dissolution of both components			2016/12/22
Auranofin	Capsule			Develop a dissolution method			2023/09/15
Avacopan	Capsule	II (Paddle) with sinker	50	0.1N HCl	900	10, 20, 30, 45 and 60	2023/10/06
Avanafil	Tablet	II (Paddle)	50	Simulated gastric fluid without pepsin.	900	5, 10, 15, 20 and 30	2015/04/02
Avapritinib	Tablet	II (Paddle)	75	0.05 M Sodium Acetate Buffer, pH 5.0 containing 0.5% w/v cetyl trimethylammonium bromide (CTAB)	900	5, 10, 15, 20, 30, 45, 60, 90 and 120	2022/05/12
Avatrombopag Maleate	Granule	I (Basket)	100	0.1% w/v CTAB in 0.05 M Sodium Phosphate Buffer, pH 6.8	900	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Avutometinib Potassium (Avu); Defactinib Hydrochloride (Def)	Capsule, Tablet	II (Paddle)		Avu: 1% Tween 60 in Phosphate Buffer, pH 7.0; Def: 0.08 N HCl	900	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Axitinib	Tablet	II (Paddle)	75	0.01 N HCl	900	5, 15, 30, 45 and 60	2014/08/14
Azacitidine	Tablet	II (Paddle)	75	50 mM phosphate buffer, pH 6.8	500	5, 10, 15, 20, 30 and 45	2023/11/30
Azacitidine	Injectable Suspension			Develop a dissolution method			2008/09/03
Azathioprine	Tablet			Develop a dissolution method			2024/01/03
Azilsartan Kamedoxomil	Tablet	II (Paddle)	50	Phosphate Buffer, pH 7.8 (deaerated)	900	5, 10, 15, 20, 30 and 45	2013/05/09
Azilsartan Kamedoxomil/Chlorthalidone	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8 containing 1.0% Tween 80,	900	5, 10, 15, 20, 30 and 45	2013/05/09
Azithromycin	Tablet			Refer to USP			2016/12/22