美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Aspirin/Dipyridamole	Capsule	I (Basket)	100	0.01 N HCl for first hour, 0.1 M Phosphate Buffer, pH 5.5, thereafter	0-1 hrs: 900 mL. 900 mL thereafter	Acid: 10, 20, 30, 45 and 60 min; Buffer:1, 2, 5, and 7 hours	2007/10/09
Aspirin/Hydrocodone Bitartrate	Tablet	II (Paddle)	75	Acetate Buffer, pH 4.5	900	10, 20, 30, 45, 60 and 90	2004/01/15
Aspirin/Meprobamate	Tablet			Develop a dissolution method			2023/09/15
Aspirin/Methocarbamol	Tablet			Develop a dissolution method			2023/09/15
Aspirin/Oxycodone HCl	Tablet			Refer to USP			2010/01/15
Atazanavir Sulfate	Capsule	II (Paddle)	50	0.025 N HCl	1000	10, 20, 30 and 45	2006/01/20
Atazanavir Sulfate/ Cobicistat	Tablet	II (Paddle)	75	0.05 M Citrate Buffer (pH 2.8)	1000	Atazanavir: 10, 15, 20, 30 and 45; Cobicistat: 5, 10, 15, 20 and 30	2015/12/24
Atenolol	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Atenolol/Chlorthalidone	Tablet			Refer to USP			2014/02/14
Atogepant	Tablet			Refer to FDA's Dissolution Guidance, 2018			2023/05/18
Atomoxetine HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Atorvastatin Calcium	Tablet	II (Paddle)	75	0.05 M Phosphate buffer, pH 6.8	900	5, 10, 15 and 30	2004/01/15
Atorvastatin Calcium	Suspension	II (Paddle)	75	0.05 M Phosphate Buffer, pH 6.8	900	5, 10, 15 and 30	2024/05/31
Atorvastatin Calcium/Ezetimibe	Tablet	II (Paddle), with option to use a sinker for 20/10 mg strength	75	Phosphate buffer, pH 6.8 with 0.2% w/v Tween 80	900	5, 10, 15, 20, 30 and 45	2014/05/15
Atovaquone	Tablet	II (Paddle)	50	40% isopropanol buffered to pH 8.0 with potassium dihydrogen phosphate	900	10, 20, 30, 45, 60 and 90	2007/06/18
Atovaquone	Oral Suspension			Develop a dissolution method			2009/07/21
Atovaquone/Proguanil HCl	Tablet	II (Paddle) with PEAK vessels	50	40% isopropranol buffered to pH 8.0 with potassium dihydrogen phosphate	900	15, 30, 45 and 60	2006/08/17
Atropine Sulfate/ Diphenoxylate HCl	Tablet			Develop dissolution method(s) to characterize the dissolution of both components			2016/12/22
Auranofin	Capsule			Develop a dissolution method			2023/09/15
Avacopan	Capsule	II (Paddle) with sinker	50	0.1N HCl	900	10, 20, 30, 45 and 60	2023/10/06