美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Asenapine Maleate	Tablet (Sublingual)	II (Paddle)	50	Acetate Buffer, pH 4.5	500	1, 2, 3, 4 and 5	2013/05/09
Aspirin	Capsule (Extended Release)	II (Paddle) with sinker	100	0.05M Potassium Phosphate Buffer (pH 7.4) with trypsin (.001%w/v) and sodium azide (.025% w/v)	900	1, 2, 3, 6, 9, 12, 16, 22 and 30 hours	2016/10/20
Aspirin	Capsule			Refer to USP			2015/05/28
Aspirin/ Omeprazole	Tablet (Delayed Release)	I (Basket)	100	Acid Stage: 0.1 N HCl (degassed); Buffer Stage: Phosphate Buffer, pH 6.8 (degassed)	Acid Stage: 900; Buffer Stage: 900	Acid Stage:120; Buffer Stage:10, 20, 30, 45, 60 and 75	2016/12/22
Aspirin/Butalbital/Caffeine	Capsule			Develop a dissolution method			2024/01/03
Aspirin/Butalbital/Caffeine	Tablet			Develop a dissolution method			2024/01/03
Aspirin/Butalbital/Caffeine/Codeine Phosphate	Capsule			Develop a dissolution method			2024/01/03
Aspirin/Caffeine/Orphenadrine Citrate	Tablet			Develop a dissolution method			2023/09/15
Aspirin/Dipyridamole	Capsule	I (Basket)	100	0.01 N HCl for first hour, 0.1 M Phosphate Buffer, pH 5.5, thereafter	0-1 hrs: 900 mL. 900 mL thereafter	Acid: 10, 20, 30, 45 and 60 min; Buffer:1, 2, 5, and 7 hours	2007/10/09
Aspirin/Hydrocodone Bitartrate	Tablet	II (Paddle)	75	Acetate Buffer, pH 4.5	900	10, 20, 30, 45, 60 and 90	2004/01/15
Aspirin/Meprobamate	Tablet			Develop a dissolution method			2023/09/15
Aspirin/Methocarbamol	Tablet			Develop a dissolution method			2023/09/15
Aspirin/Oxycodone HCl	Tablet			Refer to USP			2010/01/15
Atazanavir Sulfate	Capsule	II (Paddle)	50	0.025 N HCl	1000	10, 20, 30 and 45	2006/01/20
Atazanavir Sulfate/ Cobicistat	Tablet	II (Paddle)	75	0.05 M Citrate Buffer (pH 2.8)	1000	Atazanavir: 10, 15, 20, 30 and 45; Cobicistat: 5, 10, 15, 20 and 30	2015/12/24
Atenolol	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Atenolol/Chlorthalidone	Tablet			Refer to USP			2014/02/14
Atogepant	Tablet	II (Paddle)	75	0.1 N HCl	500	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Atomoxetine HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Atorvastatin Calcium	Tablet	II (Paddle)	75	0.05 M Phosphate buffer, pH 6.8	900	5, 10, 15 and 30	2004/01/15