美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Anagrelide HCl	Capsule	I (Basket)	100	0.1 N HCl	900	5, 10, 15, 30 and 45	2004/01/14
Anastrozole	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Apalutamide	Tablet	II (Paddle)	75	0.25% sodium lauryl sulfate (SLS) in 0.05 M Sodium Phosphate Buffer, pH 4.5 (60 mg strength); 0.5% sodium lauryl sulfate (SLS) in 0.05 M Sodium Phosphate Buffer, pH 4.5 (240 mg strength)	900	5, 10, 15, 20, 30, and 45	2024/02/16
Apixaban	For Suspension	II (Paddle)	50	0.05 M Phosphate Buffer, pH 6.8	500	5, 10, 15, 20, 30, 45 and 60	2026/03/25
Apixaban	Tablet	II (Paddle)	75	0.05 M Sodium Phosphate Buffer with 0.05% SLS, pH 6.8	900	5, 10, 20, 30 and 45	2013/05/09
Apomorphine HCl	Film (Sublingual)	V (paddle over disk)	75	20mM BIS-TRIS HCl Buffer, pH 6.4	500	2.5, 5, 7.5, 10, 12.5, 15 and 20	2021/08/19
Apremilast	Tablet	II (Paddle)	60	0.15% SLS in 25 mM Sodium Phosphate Buffer, pH 6.8	900	10, 15, 20, 30, and 45	2017/05/18
Apremilast	Tablet (Extended Release)	II (Paddle) with Sinker	75	0.5% Tween 80 in Sodium Acetate Buffer, pH 5.5	900	120, 360, 480, 600, 840, 960, 1080 and 1440	2026/05/22
Aprepitant	Emulsion			Develop a method to characterize in vitro release			2024/02/05
Aprepitant	Capsule			Develop a dissolution method			2023/09/15
Aprepitant	For Oral Suspension			Develop a dissolution method			2023/09/15
Aprocitentan	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8 w/0.05% CTAB and 0.5% Tween 20	900	10, 15, 20, 30 and 45	2025/02/24
Arimoclomol Citrate	Capsule	II (Paddle) with sinker	75	NaCl/HCl media, pH 1.2 (simulated gastric fluid without enzymes)	1000	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Aripiprazole	Suspension (Extended Release)	IV (Flow through Cell) with closed system	4 mL/min	Acetate buffer, pH 5.0	1000	0.5, 0.75, 1, 2, 4, 6, 8, 10, 12, 14, 16 and 18 hours	2024/11/01
Aripiprazole	Tablet			Refer to USP			2016/06/30
Aripiprazole	Tablet (Orally Disintegrating)	II (Paddle)	75	Acetate Buffer, pH 4.0	1000	10, 20, 30 and 45	2008/08/11
Aripiprazole	For Intramuscular Suspension (Extended Release)	II (Paddle)	50	0.25% Sodium Dodecyl Sulfate (SDS) Solution	900	10, 15, 30, 60, 120, 180, 240, 300, 360, 420 and 480	2015/06/25
Armodafinil	Tablet	II (Paddle)	50	0.1 N HCl	900	10, 20, 30 and 45	2008/01/14
Asciminib HCl	Tablet	II (Paddle)	60	Citrate Buffer, pH 3.0	900	5, 10, 15, 20 and 45	2023/10/06
Asenapine	Transdermal	VI (Cylinder)	50	pH 5.1 Acetate Buffer at 32°C	900	1, 2, 3, 4, 6, 8, 10 and 12 hours	2021/04/22