FDA药品溶出方法数据库
(FDA-Recommended Dissolution Methods Database)
药品通用名称 剂型 USP溶出装置 速度 溶出介质 介质体积 建议取样时间(分钟) 更新日期
Apremilast Tablet II (Paddle) 60 0.15% SLS in 25 mM Sodium Phosphate Buffer, pH 6.8 900 10, 15, 20, 30, and 45 2017/05/18
Aprepitant Capsule Develop a dissolution method 2023/09/15
Aprepitant Emulsion Develop a method to characterize in vitro release 2024/02/05
Aprepitant For Oral Suspension Develop a dissolution method 2023/09/15
Aprocitentan Tablet II (Paddle) 50 Phosphate Buffer, pH 6.8 w/0.05% CTAB and 0.5% Tween 20 900 10, 15, 20, 30 and 45 2025/02/24
Aripiprazole Suspension (Extended Release) IV (Flow through Cell) with closed system 4 mL/min Acetate buffer, pH 5.0 1000 0.5, 0.75, 1, 2, 4, 6, 8, 10, 12, 14, 16 and 18 hours 2024/11/01
Aripiprazole Tablet (Orally Disintegrating) II (Paddle) 75 Acetate Buffer, pH 4.0 1000 10, 20, 30 and 45 2008/08/11
Aripiprazole For Intramuscular Suspension (Extended Release) II (Paddle) 50 0.25% Sodium Dodecyl Sulfate (SDS) Solution 900 10, 15, 30, 60, 120, 180, 240, 300, 360, 420 and 480 2015/06/25
Aripiprazole Tablet Refer to USP 2016/06/30
Armodafinil Tablet II (Paddle) 50 0.1 N HCl 900 10, 20, 30 and 45 2008/01/14
Asciminib HCl Tablet II (Paddle) 60 Citrate Buffer, pH 3.0 900 5, 10, 15, 20 and 45 2023/10/06
Asenapine Transdermal VI (Cylinder) 50 pH 5.1 Acetate Buffer at 32°C 900 1, 2, 3, 4, 6, 8, 10 and 12 hours 2021/04/22
Asenapine Maleate Tablet (Sublingual) II (Paddle) 50 Acetate Buffer, pH 4.5 500 1, 2, 3, 4 and 5 2013/05/09
Aspirin Capsule Refer to USP 2015/05/28
Aspirin Capsule (Extended Release) II (Paddle) with sinker 100 0.05M Potassium Phosphate Buffer (pH 7.4) with trypsin (.001%w/v) and sodium azide (.025% w/v) 900 1, 2, 3, 6, 9, 12, 16, 22 and 30 hours 2016/10/20
Aspirin/ Omeprazole Tablet (Delayed Release) I (Basket) 100 Acid Stage: 0.1 N HCl (degassed); Buffer Stage: Phosphate Buffer, pH 6.8 (degassed) Acid Stage: 900; Buffer Stage: 900 Acid Stage:120; Buffer Stage:10, 20, 30, 45, 60 and 75 2016/12/22
Aspirin/Butalbital/Caffeine Capsule Develop a dissolution method 2024/01/03
Aspirin/Butalbital/Caffeine Tablet Develop a dissolution method 2024/01/03
Aspirin/Butalbital/Caffeine/Codeine Phosphate Capsule Develop a dissolution method 2024/01/03
Aspirin/Caffeine/Orphenadrine Citrate Tablet Develop a dissolution method 2023/09/15

数据库说明:

当前数据更新日期:2025年12月07日。
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