美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Sulfasalazine	Tablet			Refer to USP			2009/12/15
Sulfasalazine	Tablet (Delayed Release)			Refer to USP			2009/12/15
Sulfisoxazole Acetyl	Oral Suspension (Pediatric)	II (Paddle)	30	1% SLS in 0.1N HCl	900	15, 30, 45, 60 and 90	2006/08/17
Sumatriptan Succinate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Sunitinib Malate	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Sunvozertinib	Tablet	II (Paddle)	75	50 mM Citrate Buffer, pH 5.1	900	5, 10, 15, 20, 30, 45 and 60	2026/03/25
Suvorexant	Tablet			Develop a dissolution method			2023/09/15
Suzetrigine	Tablet	II (Paddle)	65	0.3% Triton X-100 in 50 mM phosphate buffer, pH 6.8	900	5, 10, 15, 20 and 30	2026/01/28
Tacrolimus	For Suspension	II (Paddle)	50	Hydroxypropyl Cellulose Solution (1 in 20,000). Adjust to pH 4.5 by Phosphoric Acid		15, 30, 45, 60, 90 and 120	2023/02/09
Tacrolimus	Capsule (Extended Release)	II (Paddle)	50	Tier I: 0.1% SLS and 0.005% hydroxypropylcellulose solution, pH 4.5; Tier II: 0.1% SLS and 0.005% hydroxypropylcellulose solution, pH 4.5 wtih 30 Gelatin Digesting Unit (GDU)/L Bromelain	900	30, 60, 90, 420 and 1440	2026/05/22
Tacrolimus	Tablet (Extended Release)	II (Paddle)	100	0.005% HPC in Water with 0.50% SLS adjusted to pH 4.5	900	0.5, 1, 2.5, 4.5, 6.5, 8.5 and 12 hours	2016/06/30
Tacrolimus	Capsule	II (Paddle)	50	Hydroxypropyl Cellulose Solution (1 in 20,000). Adjust to pH 4.5 by Phosphoric Acid	900	30, 60, 90 and 120	2004/02/20
Tadalafil	Tablet	II (Paddle)	50	0.5% Sodium Lauryl Sulfate	1000	10, 20, 30 and 45	2006/01/26
Tadalafil	Suspension			Develop a dissolution method			2026/03/25
Tafamidis	Capsule	II (Paddle) with sinker	75	Tier 1 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8 with 1.0% Tween 80; Tier II Medium: 0.05M Sodium Phosphate Buffer, pH 6.8 with 1.0% Tween 80 and enzyme with protease activity as per USP	900	5, 10, 15, 20, 30 and 45	2021/04/22
Tafamidis Meglumine	Capsule	II (Paddle) with sinker	75	Tier 1 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8. Tier 2 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8, and pancreatin with protease activity as per USP	900	5, 10, 15, 20, 30 and 45	2021/04/22
Tafenoquine Succinate	Tablet	II (Paddle)	75	0.01M Sodium phosphate buffer, pH 6.8, with 0.20% w/v of Polysorbate 20	900	5, 10, 20, 30, 45 and 60	2020/08/27
Talazoparib Tosylate	Capsule	II (Paddle) with sinker	75	0.01 N HCl with 0.2% sodium dodecyl sulfate (SDS),	500	10, 15, 20, 30 and 45	2020/08/27
Taletrectinib Adipate	Capsule	II (Paddle) with Sinker	50	0.05 M Acetic Acid - Sodium Acetate Buffer, pH 4.0	900	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Tamoxifen Citrate	Tablet			Refer to USP			2009/04/02