美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Rotigotine	Film, Extended Release	Paddle over Disk (Apparatus 5)	50	Phosphate Buffer, pH 4.5 at 32°C	900	15, 30, 60, 90, 120, 150 and 180	2009/07/15
Rucaparib	Tablet	II (Paddle)	75	0.01 N HCl	900	5, 10, 15, 20 and 30	2017/01/19
Rufinamide	Tablet			Refer to USP			2013/08/15
Rufinamide	Suspension			Develop a dissolution method			2023/09/15
Ruxolitinib Phosphate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Sacubitril/Valsartan	Tablet	I (Basket)	75	Phosphate Buffer, pH 6.8[degassed]	900	10, 15, 20, 30 and 45	2019/10/24
Sacubitril; Valsartan	Capsule, Pellets	I (Basket)	50	Phosphate Buffer, pH 6.8	900	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Safinamide Mesylate	Tablet	II (Paddle)	100	0.1 N HCL with Sodium Chloride [0.2% (wt/vol) solution], pH 1.2	900	5, 10, 15, 30, 45 and 60	2023/10/06
Sapropterin Dihydrochloride	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Saquinavir Mesylate	Tablet	II (Paddle)	50	Citrate Buffer (pH 3.0)	900	10, 20 , 30 and 45	2007/09/13
Saquinavir Mesylate	Capsule			Refer to USP			2007/09/13
Saxagliptin HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Scopolamine	System	Reciprocating disk (Apparatus 7)	Stroke depth: 2-3 cm; 30-60 cycles per minute	Distilled Water	25 × 150 mm test-tubes containing 20 mL	1, 2, 4, 6, 12, 18, 24, 36, 48, and 72 hours	2009/07/15
Sebetralstat	Tablet	II (Paddle)	50	Acetate Buffer, pH 4.5 with 0.5% SLS	1000	5, 10, 15, 20, 30, 45 and 60	2026/03/25
Secnidazole	Granule	I (Basket)	50	Phosphate Buffer, pH 6.8	900	0.5, 1, 1.5, 2, 2.5, 3, 3.5 and 4 hours	2017/11/16
Selegiline HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Selegiline (20 mg/20 cm2 and 30 mg/30 cm2)	Film, Extended Release	Paddle over Disk (Apparatus 5)	50	0.1 M Phosphate buffer, monobasic, pH 5 at 32°C	500	1, 2, 4, 8, 12, 16, 20 and 24 hours	2009/07/15
Selegiline (40 mg/40 cm2)	Film, Extended Release	Rotating Cylinder (Apparatus 6)	50	0.1 M Phosphate buffer, monobasic, pH 5 at 32°C	1000	1, 2, 4, 8, 12, 16, 20 and 24 hours	2009/07/15
Selegiline HCl	Tablet (Orally Disintegrating)			Develop a dissolution method			2023/09/15
Selexipag	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8	900	5, 10, 15, 20 and 30	2016/03/17