美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Rabeprazole Sodium	Tablet (Delayed Release)	II (Paddle)	100	700 mL 0.1 N HCl (Acid stage), after two hours add 300 mL of 0.6 M Tris buffer; adjust to pH 8.0 (Buffer stage) with 2 N HCl or 2 N NaOH . Stabilize the samples with the addition of 0.5 N NaOH	Acid stage: 700; Buffer stage: 1000	Acid stage: 120; Buffer stage: 10, 20, 30, and 45	2011/09/22
Raloxifene HCl	Tablet			Develop a dissolution method			2023/09/15
Raltegravir Potassium	Tablet (Chewable)			Develop a dissolution method			2023/09/15
Raltegravir Potassium	Tablet			Develop a dissolution method			2023/09/15
Ramelteon	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ramipril	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ramipril	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ranitidine HCl	Tablet			Develop a dissolution method			2024/01/03
Ranitidine HCl	Capsule			Develop a dissolution method			2023/09/15
Ranitidine HCl	Tablet (Effervescent)			Develop a dissolution method			2010/04/08
Ranolazine	Tablet (Extended Release)			Develop a dissolution method			2019/02/07
Ranolazine	Granules (Extended Release)	II (Paddle)	50	0.1 N HCl	900	0.5, 1, 2, 3, 4, 6 and 8 hours	2022/07/07
Rasagiline Mesylate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Regorafenib	Tablet	II (Paddle)	75	Acetate Buffer pH 4.5 with 0.1% Sodium Dodecyl Sulfate (SDS)	900	10, 15, 20, 30 and 45	2015/06/25
Relacorilant	Capsule	II (Paddle)	100	Tier I: 25 mg: 0.1 N HCl with 0.15% (w/v) Tween 80; 100 mg: 0.1 N HCl with 0.5% (w/v) Tween 80; Tier II: same as Tier I with the addition of NMT 750,000 unitl/L Pepsin	900	5, 10, 15, 20, 30, 45 and 60	2026/05/22
Relugolix	Tablet	II (Paddle)	50	50 mM Citrate Buffer, pH 5.5	900	5, 10, 15, 20 and 30	2022/07/07
Repaglinide	Tablet			Refer to USP			2007/07/25
Repotrectinib	Capsule	II (Paddle) with sinker	75	50 mM Sodium Phosphate Buffer, pH 6.8, w/ 0.075% SLS	900	5, 10, 15, 30, 45, 60 and 75	2025/06/23
Resmetirom	Tablet			Develop a dissolution method			2024/09/03
Revumenib Citrate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2026/01/28