美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Riluzole	Suspension	II (Paddle)	35	Phosphate Buffer pH 4.5	900 [890 mL of medium + 10 mL of suspension]	5, 10, 20, 30, 45 and 60	2022/05/12
Rimantadine HCl	Tablet			Develop a dissolution method			2023/09/15
Rimegepant Sulfate	Tablet, (Orally Disintegrating (ODT))	II (Paddle)	50	50 mM Sodium Acetate Buffer, pH 4.5	500	5, 10, 15, 20 and 30	2022/05/12
Rimexolone	Ophthalmic Suspension			Develop a method to characterize in vitro release			2016/06/30
Riociguat	Tablet	II (Paddle)	75	pH 6.8 Phosphate Buffer with 0.1% Sodium Lauryl Sulfate [SLS]	900	5, 10, 15, 20 and 30	2015/12/24
Ripretinib	Tablet	II (Paddle)	75	10 mM Sodium Acetate Buffer, pH 4.5, containing 0.25% (w/v) sodium dodecyl sulfate (SDS)	900	5, 10, 15, 20, 30 and 45	2022/05/12
Risedronate Sodium	Tablet (Delayed Release)	II (Paddle)	75	Acid stage: 0.1 N HCl; Buffer stage: Phosphate buffer, pH 6.8	Acid stage: 500; Buffer stage: 500	Acid stage: 120; Buffer Stage: 10, 15, 20, 30 and 45	2012/01/26
Risedronate Sodium	Tablet			Develop a dissolution method			2024/01/03
Risedronate Sodium/Calcium Carbonate	Tablet (Copackaged)			For Risedronate Tablets: Refer to USP; For Calcium Carbonate Tablets: Refer to USP.			2010/07/01
Risperidone	For Suspension (Extended Release)	IV (Flow thru cell-closed loop)		50 mM Potassium Phosphate Buffer, pH 7.4	1000	8, 24, 96, 120, 144, 168, 192, 216 and 264 hours	2025/06/23
Risperidone	Injectable			Develop a dissolution method using USP IV (Flow-Through Cell), and, if applicable, Apparatus II (Paddle) or any other appropriate method, for comparative evaluation by the Agency			2010/01/15
Risperidone	Tablet	II (Paddle)	50	0.1 N HCl	500	10, 20, 30, 45 and 60	2006/03/04
Risperidone	Tablet (Orally Disintegrating)	II (Paddle)	50	0.1 N HCl	500	5, 10, 15	2004/07/23
Ritlecitinib Tosylate	Capsule			Refer to FDA's Dissolution Guidance, 2018			2024/11/01
Ritonavir	Powder	I (Basket -100 mesh)	100	0.1 N HCl	900	5, 10, 15, 20 and 30	2017/11/16
Ritonavir	Tablet			Develop a dissolution method			2025/09/08
Ritonavir	Capsule			Refer to USP			2015/01/15
Rivaroxaban (10 mg)	Tablet	II (Paddle)	75	Acetate Buffer pH 4.5, 0.2% sodium dodecyl sulfate (SDS)	900	10, 15, 20, 30 and 45	2015/01/15
Rivaroxaban (15 and 20 mg)	Tablet	II (Paddle)	75	Acetate Buffer pH 4.5, 0.4% SDS	900	10, 15, 20, 30 and 45	2015/01/15
Rivaroxaban (2.5 mg)	Tablet	II (Paddle)	75	Acetate Buffer pH 4.5	900	10, 15, 20, 30 and 45	2019/02/07