美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Pyrazinamide	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Pyridostigmine Bromide	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Pyridostigmine Bromide	Tablet (Extended Release)			Develop a dissolution method			2023/09/15
Pyrimethamine	Tablet			Refer to USP			2015/06/25
Quetiapine Fumarate	Tablet (Extended Release)	I (Basket, with 20 mesh)	200	0.05M citric acid and 0.09 N NaOH (pH 4.8) [solution A]. At 5 hrs, pH adjusted to 6.6 by addition of 100 mL of 0.05M dibasic sodium phosphate and 0.46N NaOH [solution B]	900 [solution A]. 1000 [final]	1, 2, 4, 6, 8, 10, 12, 16, 20, and 24 hours	2013/01/31
Quetiapine Fumarate	Tablet			Develop a dissolution method			2023/09/15
Quinapril HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Quinidine Gluconate	Tablet (Extended Release)			Refer to USP			2021/04/22
Quinine Sulfate	Capsule			Refer to USP			2008/01/14
Quizartinib Dihydrochloride	Tablet	II (Paddle)	50	0.1 N HCl	900	15, 20, 30, 45, and 60	2024/11/01
Rabeprazole Sodium	Tablet (Delayed Release)	II (Paddle)	100	700 mL 0.1 N HCl (Acid stage), after two hours add 300 mL of 0.6 M Tris buffer; adjust to pH 8.0 (Buffer stage) with 2 N HCl or 2 N NaOH . Stabilize the samples with the addition of 0.5 N NaOH	Acid stage: 700; Buffer stage: 1000	Acid stage: 120; Buffer stage: 10, 20, 30, and 45	2011/09/22
Rabeprazole Sodium	Capsule (Delayed Release)	II (Paddle)	Acid Stage: 75 rpm; Buffer Stage: 60 rpm	Acid Stage:0.1 N HCl; Buffer Stage: 0.05 M Phosphate Buffer, pH 6.8 (After Acid Stage, add 250 mL of 0.2 mol/L trisodium phosphate solution).	Acid Stage: 750; Buffer Stage:1000	Acid Stage: 120; Buffer Stage: 10, 15, 20, 25, 30 and 45	2014/05/15
Raloxifene HCl	Tablet			Develop a dissolution method			2023/09/15
Raltegravir Potassium	Tablet			Develop a dissolution method			2023/09/15
Raltegravir Potassium	Tablet (Chewable)			Develop a dissolution method			2023/09/15
Ramelteon	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ramipril	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ramipril	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ranitidine HCl	Tablet (Effervescent)			Develop a dissolution method			2010/04/08
Ranitidine HCl	Tablet			Develop a dissolution method			2024/01/03