美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Pitavastatin Calcium	Tablet	I (Basket)	35	0.05 M Phosphate Buffer, pH 6.8	900	5, 10, 15, 20, 30 and 45	2010/12/23
Pomalidomide	Capsule	II (Paddle)	50	0.1 N HCl	900	10, 15, 20, 30 and 45	2015/05/28
Ponatinib HCl	Tablet	I (Basket)	50	pH 2.1, KCl/HCl buffer (degassed)	900	10, 15, 20, 30, 45 and 60	2015/09/03
Posaconazole	For Suspension (Delayed Release)	II (Paddle)	75	Acid stage: 0.01 N HCl; Buffer stage: pH 6.8 Phosphate buffer with 1.3% Tween 80;	Acid stage: 750 mL; Buffer stage: 1000 mL	Acid stage: 120; Buffer stage: 5, 10, 15, 20, 30 and 45	2022/07/07
Posaconazole	Tablet (Delayed Release)	II (Paddle)	75	Acid Stage: 0.01 N HCl: Buffer Stage: 50 mM phosphate buffer, pH 6.8 with 0.37 % Polysorbate 80 (after 120 minutes, to the acid stage, add 250 mL of 0.2M Phosphate Buffer, 1.46% Polysorbate 80)	Acid Stage: 750 mL; Buffer Stage 1000 mL	Acid Stage: 120; Buffer Stage: 10, 15, 20, 30 and 45	2015/06/25
Posaconazole	Oral Suspension	II (Paddle)	25	0.3% SLS	900	10, 20, 30 and 45	2007/12/03
Potassium Chloride	Tablet (Extended Release)			Develop a dissolution method			2024/01/03
Potassium Chloride	Capsule (Extended Release)			Develop a dissolution method			2024/01/03
Potassium chloride	For suspension, Extended Release			Develop a dissolution method			2026/01/28
Potassium Citrate	Tablet			Develop a dissolution method			2024/01/03
Pralsetinib	Capsule	II (Paddle) with sinker	50	50 mM Sodium Phosphate Buffer, pH 6.8, with 0.4% w/v Cetyl Trimethylammonium Bromide (CTAB)	900	10, 20, 30, 45 and 60	2022/07/07
Pramipexole Dihydrochloride	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Pramipexole Dihydrochloride	Tablet (Extended Release)	I (Basket)	100	0.05 M phosphate buffer, pH 6.8	500	1, 2, 4, 6, 9, 12, 16, 20 and 24 hours	2010/09/02
Prasugrel HCl	Tablet	II (Paddle)	75	Citrate-Phosphate buffer (0.023M Citric acid+0.026M Sodium Phosphate, Dibasic), pH 4.0	900	10, 15, 20, 30 and 45	2012/10/04
Pravastatin Sodium	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Praziquantel	Tablet			Refer to USP			2015/06/25
Prazosin HCl	Capsule			Refer to USP			2022/05/12
Prednisolone	Tablet			Develop a dissolution method			2024/01/03
Prednisolone Acetate	Ophthalmic Suspension			Develop an in vitro release method			2014/05/15
Prednisolone Sodium Phosphate	Tablet (Orally Disintegrating)	II (Paddle)	50	22 mM Sodium Acetate Buffer, pH 4.5	500	5, 15, 30, 45 and 60	2008/09/03