美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Diltiazem HCl	Tablet (Extended Release)	II (Paddle)	100	Phosphate Buffer, pH 5.8	900	2, 8, 14, and 24 hours	2008/02/19
Diltiazem HCl	Capsule (Extended Release)			Develop a dissolution method			2024/01/03
Dimethyl Fumarate	Capsule (Delayed Release)	II (Paddle)	100	Acid stage: 0.1 N HCl; Buffer stage: pH 6.8 Phosphate Buffer	Acid stage: 500; Buffer stage: 500	Acid stage: 2 hours; Buffer stage: 5, 10, 20, 30 and 45	2016/06/02
Dinoprostone	Vaginal Insert (Extended Release)			Develop a dissolution method			2023/09/15
Dinoprostone	Vaginal Suppository			Develop a method to characterize in vitro release			2012/10/04
Diphenhydramine Citrate/Ibuprofen	Tablet	II (Paddle)	50	50 mM Phosphate Buffer, pH 6.5	900	10, 20, 30 and 45	2008/01/14
Diphenhydramine HCl/Ibuprofen	Capsule	I (Basket)	100	200 mM Phosphate Buffer, pH 7.2	900	10, 20, 30 and 45	2008/01/14
Dipyridamole	Tablet			Refer to USP			2007/06/18
Diroximel Fumarate	Capsule (Delayed Release)	II (Paddle) with sinker	75	Acid Stage: 0.1 N HCl; Buffer Stage: Na.Phosphate Buffer, pH 6.5		Acid Stage: 120; Buffer Stage: 10, 20, 30, 45, 60, 75 and 90	2020/04/02
Disopyramide Phosphate	Capsule (Extended Release)			Refer to USP			2008/11/04
Disopyramide Phosphate	Capsule			Develop a dissolution method			2024/01/03
Disulfiram	Tablet	II (Paddle)	100	2% SDS	900	15, 30, 45, 60, 75, 90, 105, and 120	2007/06/18
Divalproex Sodium	Tablet (Delayed Release)			Refer to USP			2007/07/25
Divalproex Sodium	Tablet (Extended Release)			Refer to USP			2016/06/30
Divalproex Sodium	Capsule (Delayed Release)			Refer to USP			2016/06/30
Dofetilide	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dolasetron Mesylate	Tablet			Develop a dissolution method			2024/01/03
Dolutegravir Na/Rilpivirine HCl	Tablet	II (Paddle)	75	1.0 % Tween 20 in 0.01 M HCl, pH 2.0	900	10, 15, 20, 30, 45 and 60	2018/02/08
Dolutegravir Sodium (10 mg)	Tablet	II (Paddle)	50	0.01M pH 6.8 phosphate buffer	900	5, 10, 15, 20, 30 and 45	2018/10/18
Dolutegravir Sodium (25 mg)	Tablet	II (Paddle)	50	0.01M pH 6.8 phosphate buffer containing 0.15% w/v sodium dodecyl sulfate (SDS)	900	5, 10, 15, 20, 30 and 45	2018/10/18