美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Doxazosin Mesylate	Tablet	II (Paddle)	50	0.01 N HCl	900	10, 20, 30, 45 and 60	2004/01/27
Doxazosin Mesylate	Tablet (Extended Release)	II (Paddle)	75	SGF without enzyme	900	1, 2, 4, 6, 8, 12 and 16 hours	2007/01/03
Doxepin HCl	Tablet	II (Paddle)	50	Simulated Gastric Fluid w/o enzyme (pH 1.1-1.3)	900	5, 10, 15, 20, 30 and 45	2010/09/02
Doxepin HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Doxepin HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Doxercalciferol	Capsule			Develop a quantitative rupture test			2008/06/03
Doxorubicin HCl	Injectable (Liposomal)			Develop a method to characterize in vitro release, starting at pH 6.00 ± 0.05 and at 47ºC ± 0.5ºC. Replicate for 12 dosage vials.			2012/10/04
Doxycycline	Capsule (Delayed Release)	II (Paddle)	75	Dilute HCl, pH 1.1 for 2 hours and then add 200 mL of 0.1 N NaOH in 200 mM Phosphate Buffer. Adjust pH to 6.0 using 2 N HCl and/or 2N NaOH	Acid stage: 750; Buffer stage: 950	1, 2, 2.5 , 3 and 4 hours	2008/10/06
Doxycycline	Suspension	II (Paddle)	25	0.01 N HCl	900	5, 10, 15 and 20	2008/09/03
Doxycycline Calcium	Suspension			Develop a dissolution method			2019/03/07
Doxycycline Hyclate	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Doxycycline Hyclate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Doxycycline Hyclate ( 120 mg and 60 mg)	Tablet (Delayed Release)	I (Basket)	100	Acid stage: 0.06 N HCl; Buffer stage: Neutralized Phthalate Buffer, pH 5.5	Acid stage: 900 mL; Buffer stage: 900 mL	Acid stage: 10, 20, 30, 45 and 60; Buffer stage: 5, 10, 15, 20, 30 and 45	2018/03/27
Doxycycline Hyclate ( 150 mg and 75 mg)	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Doxycycline Hyclate ( 200 mg, 150 mg, 100 mg, 80 mg and 75 mg)	Tablet (Delayed Release)			Refer to USP			2015/05/28
Doxycycline Hyclate ( 50 mg)	Tablet (Delayed Release)	I (Basket)	100	Acid stage: 0.06 N HCl; Buffer stage: Neutralized Phthalate Buffer, pH 5.5	900	Acid stage: 5, 10, 15, 20 and 30; Buffer stage: 5, 10, 15, 20 and 30	2015/05/28
Doxylamine Succinate/Pyridoxine HCl	Tablet (Extended Release)	II (Paddle)	100	Acid stage: 0.1 N HCl: Buffer stage: 0.2M sodium phosphate buffer pH 6.8	Acid stage: 1000 mL; Buffer stage: 1000 mL	Acid stage: 5, 10, 15, 30, 60, 120; Buffer stage: 5, 10, 15, 20 and 30	2017/01/19
Dronabinol	Capsule			Develop a dissolution method; (In addition, the USP capsule rupture test should also be conducted)			2023/09/15
Dronedarone HCl	Tablet	II (Paddle) with sinker	75	pH 4.5 Phosphate buffer	1000	10, 15, 20, 30, 45, 60, 90 and 120	2015/02/25
Drospirenone/Estetrol	Tablet	II (Paddle)	50	Phosphate Buffer pH 6.8	900	5,10, 15, 20 and 30	2023/03/30