FDA药品溶出方法数据库
(FDA-Recommended Dissolution Methods Database)
药品通用名称 剂型 USP溶出装置 速度 溶出介质 介质体积 建议取样时间(分钟) 更新日期
Diclofenac Potassium Capsule II (Paddle 50 50 mM Phosphate buffer pH 6.8 900 10, 15, 20, 30 and 45 2010/10/21
Diclofenac Potassium Tablet II (Paddle) 50 SIF without enzyme 900 10, 20, 30, 45, 60 and 90 2004/01/27
Diclofenac Sodium Tablet (Extended Release) Refer to USP 2009/06/10
Diclofenac Sodium Tablet (Delayed Release) Refer to USP 2009/06/10
Diclofenac Sodium/Misoprostol Enteric Coated Tablet (Delayed Release) II (Paddle) (diclo) 100 (diclo) Diclofenac: Acid Stage: 0.1 N HCl Buffer Stage: 750ml 0.1N HCL+250ml 0.2M phos.buffer, pH 6.8 (Method A) Misoprostol: Develop a dissolution method Diclo: Acid: 750 Buffer:1000 Diclo.: 120 (acid) 15, 30, 45 and 60 (Buffer) 2023/09/15
Dicloxacillin Sodium Capsule Develop a dissolution method 2024/01/03
Dicyclomine Hydrochloride Tablet Refer to USP 2022/05/12
Didanosine Tablet (Chewable) Develop a dissolution method 2023/09/15
Didanosine Capsule (Delayed Release Pellets) I (Basket) 100 Acid stage: 0.1 N HCl; Buffer stage: 0.1 N HCl:0.2M Tribasic Sodium Phosphate (3:1), pH 6.8 1000 Acid stage: 60, 90 and 120; Buffer stage: 10, 20, 30, 45 and 60 2004/01/26
Dienogest/Estradiol Valerate Tablet Develop a dissolution method 2023/09/15
Diethylpropion HCl Tablet (Extended Release) Develop a dissolution method 2023/09/15
Diflunisal Tablet Refer to USP 2008/04/15
Digoxin Tablet Refer to USP 2007/06/18
Diltiazem HCl Tablet (Extended Release) II (Paddle) 100 Phosphate Buffer, pH 5.8 900 2, 8, 14, and 24 hours 2008/02/19
Diltiazem HCl Capsule (Extended Release) Develop a dissolution method 2024/01/03
Dimethyl Fumarate Capsule  (Delayed Release) II (Paddle) 100 Acid stage: 0.1 N HCl; Buffer stage: pH 6.8 Phosphate Buffer Acid stage: 500; Buffer stage: 500 Acid stage: 2 hours; Buffer stage: 5, 10, 20, 30 and 45 2016/06/02
Dinoprostone Vaginal Suppository Develop a method to characterize in vitro release 2012/10/04
Dinoprostone Vaginal Insert (Extended Release) Develop a dissolution method 2023/09/15
Diphenhydramine Citrate/Ibuprofen Tablet II (Paddle) 50 50 mM Phosphate Buffer, pH 6.5 900 10, 20, 30 and 45 2008/01/14
Diphenhydramine HCl/Ibuprofen Capsule I (Basket) 100 200 mM Phosphate Buffer, pH 7.2 900 10, 20, 30 and 45 2008/01/14

数据库说明:

当前数据更新日期:2025年12月09日。
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