美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Demeclocycline HCl	Tablet			Develop a dissolution method			2024/01/03
Desipramine HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Desloratadine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Desloratadine	Tablet (Orally Disintegrating)	II (Paddle)	50	0.1 N HCl	900	3, 6, 10, 15	2007/06/18
Desloratadine/Pseudoephedrine Sulfate (2.5 mg/120 mg)	Tablet (Extended Release)	II (Paddle)	50	First hour: 0.1 N HCl; After 1 hour: 0.1M Potassium Phosphate Buffer pH 7.5	1000	For Desloratadine: 10, 20, 30 and 45; For Pseudoephedrine Sulfate: 1, 2, 6 and 8 hours	2009/04/02
Desloratadine/Pseudoephedrine Sulfate (5 mg/240 mg)	Tablet (Extended Release)	II (Paddle)	50	First hour: 0.1 N HCl; After 1 hour: 0.1M Potassium Phosphate Buffer pH 7.5	1000	For Desloratadine: 10, 20, 30 and 45; For Pseudoephedrine Sulfate: 1, 2, 4, 8, 16 and 24 hours	2009/04/02
Desmopressin Acetate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Desogestrel/Ethinyl Estradiol	Tablet			Refer to USP			2008/11/04
Desvenlafaxine Succinate	Tablet (Extended Release)			Develop a dissolution method			2023/09/15
Deucravacitinib	Tablet	II (Paddle)	75	50 mM potassium phosphate buffer, pH 6.3 with 0.01% (w/v) Brij®35	1000	10, 20, 30, 45 and 60	2023/11/30
Deuruxoutinib Phosphate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2026/01/28
Deutetrabenazine	Tablet, Extended Release	II (Paddle) with sinker	75	50 mM Potassium Biphthalate pH 3.0	500	1, 2, 4, 6, 8, 10, 12, 16 and 20 hours	2025/06/23
Deutetrabenazine	Tablet	II (Paddle) over a disk (62 mm with 16 mesh)	75	pH 3.0 Acid Phthalate Buffer	500	0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours	2017/11/02
Deutivacaftor (Deu); Tezacaftor (Tez); Vanzacaftor Calcium (Van)	Tablet	II (Paddle)	75	Van and Deu: 0.5% (w/v) SLS in 50 mM sodium phosphate, pH 6.8; Tez: 0.2% (w/v) SLS solution in 0.1 N HCl	900	5, 10, 15, 20, 30, 45, 60 and 75	2026/01/28
Dexamethasone	Insert			Develop a method to characterize in vitro release			2026/03/25
Dexamethasone	Implant (Intravitreal)	VII (with reciprocating 50 mesh baskets)	30 cycles per min	Phosphate Buffered Saline containing 0.05 g/L sodium dodecyl sulfate at 45 ± 0.5°C	30	12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours	2010/10/21
Dexamethasone	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dexamethasone/Neomycin Sulfate/ Polymyxin B Sulfate	Ophthalmic Suspension			Develop a method to characterize in vitro release			2018/02/15
Dexamethasone/Tobramycin	Ophthalmic Suspension			Develop a method to characterize in vitro release			2009/04/02
Dexbrompheniramine Maleate/Pseudoephedrine Sulfate	Tablet (Extended Release)	III (Reciprocating Cylinder)	12 dpm	0.02N HCl (2 hours) followed by 0.05M Phosphate Buffer pH 7.5	250	0.5, 1, 2, 3, 4, 6 and 8 hours	2015/05/28