美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Dexbrompheniramine Maleate/Pseudoephedrine Sulfate	Tablet (Extended Release)	III (Reciprocating Cylinder)	12 dpm	0.02N HCl (2 hours) followed by 0.05M Phosphate Buffer pH 7.5	250	0.5, 1, 2, 3, 4, 6 and 8 hours	2015/05/28
Dexlansoprazole	Tablet (Delayed Release, Orally Disintegrating)	I (Basket -100 mesh)	100	Acid Stage: 0.1 N HCl; Buffer Stage: pH 7.2 Phosphate Buffer with 5 mM Sodium lauryl sulfate	Acid Stage: 500 mL; Buffer Stage: 900 mL	Acid Stage: 120; Buffer Stage: 10, 15, 20, 30, 50, 60, 75 and 90	2016/07/28
Dexlansoprazole	Capsule (Delayed Release)	I (Basket)	100	Acid Stage: 0.1 N HCl, Buffer Stage: pH 7.0 Phosphate Buffer with 5 mM SLS	Acid Stage: 500; Buffer stage: 900	Acid Stage: 120; Buffer Stage: 10, 20, 40, 50, 60 , 75, 105 and 120	2010/08/05
Dexmedetomidine HCl	Sublingual Film	V (Paddle over disk)	50	Simulated saliva	500	5, 10, 15, 20 and 30	2023/05/31
Dexmethylphenidate HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dexmethylphenidate HCl	Capsule (Extended Release)	I (Basket)	100	First 2 hours: 0.01 N HCl, Hours 2-10: Phosphate Buffer, pH 6.8	Acid: 500, Buffer: 500	0.5, 1, 2, 4, 6, and 10 hours	2008/01/14
Dexmethylphenidate HCl; Serdexmethylphenidate Chloride	Capsule			Refer to FDA's Dissolution Guidance, 2018			2023/05/18
Dextroamphetamine	Transdermal System	VI (Cylinder)	50	50 mM potassium phosphate buffer, pH 6.8		5, 10, 15, 30, 45, 60, 120, 180, 240, 300 and 360	2023/11/30
Dextroamphetamine Sulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dextroamphetamine Sulfate	Capsule (Extended Release)	I ( Basket)	100	0.1 N HCl	500	1, 4, 8 and 12 hours	2008/11/25
Dextroamphetamine Sulfate	Tablet			Develop a dissolution method			2023/09/15
Dextromethophan HBr/Guaifenesin	Tablet (Extended Release)	I (Basket)	50	0.01 N HCl	900	1, 2, 6, and 12 hours	2008/11/25
Dextromethorphan Hydrobromide/Quinidine Sulfate	Capsule	I (Basket)	100	pH 1.2, Simulated Gastric Fluid without enzyme	900	5, 10, 15, 20 and 30	2012/01/05
Dextromethorphan Polistirex	Suspension (Extended Release)	II (Paddle)	50	0.1 N HCl	500	30, 60, 90 and 180	2008/10/06
Diazepam	Film			Develop a dissolution method			2025/06/23
Diazepam	Tablet			Refer to USP			2007/07/25
Diazoxide	Oral suspension			Develop a dissolution method			2014/02/14
Diclofenac	Capsule	I (Basket)	100	10 mM Citrate Buffer pH 5.5 with 0.05% Sodium Dodecyl Sulfate (SDS)	900	5, 10, 20, 30 and 45	2015/06/25
Diclofenac Epolamine	Topical patch	V (Paddle over Disk) with a watchdish (a diameter of 6 cm)	50	pH 6.8 phosphate buffer at 32 ± 0.5°C	500	15, 30, 45, 60, 90, 120 and 180	2010/10/21
Diclofenac Potassium	Powder for Oral Solution	II (Paddle	75	0.05M phosphate buffer (TriSodium Phosphate Dodecahydrate in 0.1 N HCl and pH adjusted to 6.8)	400	2.5, 5, 7.5 and 10	2010/10/21