美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Deutetrabenazine	Tablet	II (Paddle) over a disk (62 mm with 16 mesh)	75	pH 3.0 Acid Phthalate Buffer	500	0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours	2017/11/02
Deutetrabenazine	Tablet, Extended Release	II (Paddle) with sinker	75	50 mM Potassium Biphthalate pH 3.0	500	1, 2, 4, 6, 8, 10, 12, 16 and 20 hours	2025/06/23
Deutivacaftor (Deu); Tezacaftor (Tez); Vanzacaftor Calcium (Van)	Tablet	II (Paddle)	75	Van and Deu: 0.5% (w/v) SLS in 50 mM sodium phosphate, pH 6.8; Tez: 0.2% (w/v) SLS solution in 0.1 N HCl	900	5, 10, 15, 20, 30, 45, 60 and 75	2026/01/28
Dexamethasone	Implant (Intravitreal)	VII (with reciprocating 50 mesh baskets)	30 cycles per min	Phosphate Buffered Saline containing 0.05 g/L sodium dodecyl sulfate at 45 ± 0.5°C	30	12, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 hours	2010/10/21
Dexamethasone	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dexamethasone/Neomycin Sulfate/ Polymyxin B Sulfate	Ophthalmic Suspension			Develop a method to characterize in vitro release			2018/02/15
Dexamethasone/Tobramycin	Ophthalmic Suspension			Develop a method to characterize in vitro release			2009/04/02
Dexbrompheniramine Maleate/Pseudoephedrine Sulfate	Tablet (Extended Release)	III (Reciprocating Cylinder)	12 dpm	0.02N HCl (2 hours) followed by 0.05M Phosphate Buffer pH 7.5	250	0.5, 1, 2, 3, 4, 6 and 8 hours	2015/05/28
Dexlansoprazole	Capsule (Delayed Release)	I (Basket)	100	Acid Stage: 0.1 N HCl, Buffer Stage: pH 7.0 Phosphate Buffer with 5 mM SLS	Acid Stage: 500; Buffer stage: 900	Acid Stage: 120; Buffer Stage: 10, 20, 40, 50, 60 , 75, 105 and 120	2010/08/05
Dexlansoprazole	Tablet (Delayed Release, Orally Disintegrating)	I (Basket -100 mesh)	100	Acid Stage: 0.1 N HCl; Buffer Stage: pH 7.2 Phosphate Buffer with 5 mM Sodium lauryl sulfate	Acid Stage: 500 mL; Buffer Stage: 900 mL	Acid Stage: 120; Buffer Stage: 10, 15, 20, 30, 50, 60, 75 and 90	2016/07/28
Dexmedetomidine HCl	Sublingual Film	V (Paddle over disk)	50	Simulated saliva	500	5, 10, 15, 20 and 30	2023/05/31
Dexmethylphenidate HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dexmethylphenidate HCl	Capsule (Extended Release)	I (Basket)	100	First 2 hours: 0.01 N HCl, Hours 2-10: Phosphate Buffer, pH 6.8	Acid: 500, Buffer: 500	0.5, 1, 2, 4, 6, and 10 hours	2008/01/14
Dexmethylphenidate HCl; Serdexmethylphenidate Chloride	Capsule			Refer to FDA's Dissolution Guidance, 2018			2023/05/18
Dextroamphetamine	Transdermal System	VI (Cylinder)	50	50 mM potassium phosphate buffer, pH 6.8		5, 10, 15, 30, 45, 60, 120, 180, 240, 300 and 360	2023/11/30
Dextroamphetamine Sulfate	Tablet			Develop a dissolution method			2023/09/15
Dextroamphetamine Sulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Dextroamphetamine Sulfate	Capsule (Extended Release)	I ( Basket)	100	0.1 N HCl	500	1, 4, 8 and 12 hours	2008/11/25
Dextromethophan HBr/Guaifenesin	Tablet (Extended Release)	I (Basket)	50	0.01 N HCl	900	1, 2, 6, and 12 hours	2008/11/25
Dextromethorphan Hydrobromide/Quinidine Sulfate	Capsule	I (Basket)	100	pH 1.2, Simulated Gastric Fluid without enzyme	900	5, 10, 15, 20 and 30	2012/01/05