美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Dapagliflozin Propanediol/ Metformin HCl	Tablet (Extended Release)	I (Basket- 20 mesh)	100	Phosphate Buffer, pH 6.8	1000	Dapagliflozin: 5, 10, 15, 20, 30 and 45 minutes: Metaformin: 0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours	2015/08/27
Dapagliflozin/Saxagliptin HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/08/27
Daprodustat	Tablet	II (Paddle)	50	30 mM Phosphate Buffer, pH 6.8	500 for 1 mg; 900 for 2, 4, 6 and 8 mg	5, 10, 15, 20, 25, 30, 45 and 60	2024/05/31
Dapsone	Tablet			Refer to USP			2010/12/23
Dapsone	Gel (Topical)			Develop a method to characterize in vitro release			2016/07/28
Daridorexant HCl	Tablet	II (Paddle)	75	pH 1.2 (NaCl/HCl)	900	5, 10, 15 and 30	2023/05/18
Darifenacin Hydrobromide	Tablet (Extended Release)	I (Basket)	100	0.01N HCl	900	1, 4, 8, 12, 16, 20 and 24 hours	2006/01/20
Darolutamide	Tablet	II (Paddle)	75	1% sodium lauryl sulfate (SLS) in 0.01N HCl	1000	15, 30, 45, 60, 75 and 90	2020/01/30
Darunavir Ethanolate	Oral Suspension	II (Paddle)	75	0.05% Polysorbate 20 in 0.05M Phosphate Buffer, pH 6.8	900	5, 10, 15, 20, 30 and 45	2015/06/25
Darunavir Ethanolate	Tablet	II (Paddle)	75	2% Tween-20 in 0.05 M Sodium Phosphate Buffer, pH 3.0	900	10, 20, 30, and 45	2007/09/13
Darunavir(Drv)/Cobicistat (Cobi)/Emtricitabine (Emt)/Tenofovir Alafenamide Fumarate (Taf)	Tablet	II (Paddle)	75	Drv: 0.05 M Sodium Phosphate Buffer, pH 3.0, 2% Tween 20; For Cobi, Emt and Taf: Citrate Phosphate Buffer, pH 4.2	900	Drv: 10, 15, 20, 30 and 45; For Cobi, Emt and Taf: 5, 10, 15, 20 and 30	2022/07/07
Dasabuvir Na/ Ombitasvir/Paritaprevir/Ritonavir	Tablet (Extended Release)	III (Reciprocating Cylinder [40 mesh (for bottom and top of the inner tube)]	25 dpm	15 mM hexadecyltrimethylammonium bromide (CTAB) in 0.03M Sodium Phosphate Buffer, pH 6.8	250	Ombitasvir/ Paritaprevir/ Ritonavir: 10, 15, 20, 30, 45, 60 and 90 minutes;Dasabuvir: 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24 hours	2016/10/20
Dasatinib	Tablet	II (Paddle)	60	pH 4.0 Acetate buffer containing 1% Triton X-100	1000	10, 15, 30 and 45	2009/10/30
Deferasirox	Tablet	II (Paddle)	75	0.5% Tween 20 in Phosphate Buffer, pH 6.8	900	5, 10, 15, 20 and 30	2016/03/17
Deferasirox	Tablet (for Oral Suspension)	II (Paddle)	50	Phosphate buffer pH 6.8 with 0.5% Tween 20	900	10, 20, 30 and 45	2006/06/21
Deferasirox	Granule	II (Paddle)	75	Phosphate Buffer, pH 6.8 with 0.5% Tween 20	900	5, 10, 15, 20 and 30	2017/11/02
Deferiprone	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Deferiprone (1 GM)	Tablet	I (Basket)	100	Acidic Stage: 0.1 N HCl, Buffer Stage: 0.05 M Phosphate buffer, pH 6.8.		Acid Stage: 2 hours; Buffer Stage: 1, 2, 3 and 4 hours	2022/07/07
Deflazacort	Suspension	II (Paddle)	25	Simulated Gastric Fluid, pH 1.2	500	5, 10, 15 and 30	2023/07/07
Deflazacort	Tablet	II (Paddle)	50	50 mM Phosphate buffer w/0.3% SLS, pH 6.8	500	5, ,15, 30 and 45	2023/07/07