美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Codeine Sulfate	Tablet			Refer to USP			2011/09/01
Colchicine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Colchicine	Capsule			Develop a dissolution method			2023/09/15
Colesevelam HCl	Tablet			Disintegration Testing as per USP <701> in various media such as simulated gastric fluid and simulated intestinal fluid.			2010/10/28
Crinecerfont	Capsule	I (Basket)	100	Tier 1 Medium: 0.6% SDS in 0.1 N HCl Tier 2 Medium: (first 12 min: 0.1 N HCl + pepsin 750,000 units/L), after 12 min add 100 mL of 5.5% SDS in 0.1 N HCl		15, 20, 30, 45 and 60	2026/01/28
Crizotinib	Capsule	I (Basket)	100	0.1N HCl (degassed)	900	5, 10, 15, 30 and 45	2016/04/14
Crofelemer	Tablet (Delayed Release)	II (Paddle)	75	Acid stage: 0.1 N HCl; Buffer stage: Sodium phosphate buffer, pH 6.8	Acid stage: 750; Buffer stage: 1000	Acid stage: 2 hours; Buffer stage: : 5, 10, 20, 30 and 45 minutes	2016/06/02
Cyclobenzaprine	Capsule (Extended Release)			Refer to USP			2016/10/20
Cyclobenzaprine HCl	Tablet			Refer to USP			2007/07/25
Cyclophosphamide	Tablet			Develop a dissolution method			2023/09/15
Cycloserine	Capsule			Develop a dissolution method			2024/01/03
Cyclosporine (100 mg) (AB1)	Capsule (Liquid filled)	II (Paddle)	75	0.1 N HCl containing 4 mg of N,N-dimethydodecylamine-N-oxide per mL	1000	10, 20, 30, 45, 60 and 90	2008/01/14
Cyproheptadine HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Cysteamine Bitartrate	Capsule	I (Basket)	75	0.1 N HCl	900	10, 20, 30 and 45	2004/01/24
Cysteamine Bitartrate	Granule (Delayed Release)	I (Basket	75 rpm (for 75 mg strength); 150 rpm (for 300 mg strength)	Acid Stage: 0.1 N HCl; Buffer Stage: 0.2M Sodium Phosphate buffer, pH 6.8	Acid Stage: 1000; Buffer Stage:1000	Acid Stage: 120; Buffer Stage: 5, 10, 15, 20 and 30	2020/08/27
Cysteamine Bitartrate	Capsule (Delayed Release)	I (Basket)	75	Acid stage: 0.1N HCl; Buffer stage: 0.05 M Sodium Phosphate buffer, pH 6.8	Acid stage: 1000; Buffer stage: 1000	Acid stage: 2 hours; Buffer stage: : 5, 10, 15, 20 and 30 minutes	2015/08/27
Dabigatran Etexilate Mesylate	Capsule	I (Basket) for 75 strength: I (Basket with modified diameter of 24.5 mm) for 150 mg strength:	100	0.01 N HCl (pH 2.0)	900	10, 20, 30, and 45	2011/09/22
Dabrafenib Mesylate	Capsule	II (Paddle)	65	0.2% Cetyl trimethylammonium bromide (CTAB) in 0.1N HCl	900	10, 15, 20, 30 and 45	2015/05/28
Daclatasvir Dihydrochloride	Tablet	II (Paddle)	75	Phosphate Buffer, pH 6.8 with 0.75% Brij 35	1000	10, 15, 20, 30 and 45	2016/03/17
Dalfampridine	Tablet (Extended Release)	II (Paddle)	50	Phosphate Buffer, pH 6.8	900	0.5, 1, 2, 4, 6, 8, 10 and 12 hours	2012/06/07