美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Clotrimazole	Lozenge			Refer to USP			2008/10/06
Clozapine	Suspension	II (Paddle)	50	Acetate Buffer (pH 4.0)	900	5, 10, 15, 20 and 30	2015/05/28
Clozapine	Tablet (Orally Disintegrating)	II (Paddle	50 RPM (12.5 mg, 25 mg and 100 mg); 75 RPM (150 mg and 200 mg)	pH 4.5 Acetate Buffer	900	5, 10, 15, 20, and 30	2011/06/09
Clozapine	Tablet			Refer to USP			2011/07/21
Cobicistat	Tablet	II (Paddle)	75	50 mM Sodium Acetate Buffer, pH 4.5	900	5, 10, 15, 20 and 30	2015/08/27
Cobicistat (Cobi)/ Darunavir Ethanolate (Drv)	Tablet	Cobi: II (Paddle): Drv: II (Paddle)	Cobi: 75; Drv:75	Cobi: 0.05 M Citrate Phosphate Buffer, pH 4.2; Drv: 0.05 M Sodium Phosphate Buffer, pH 3.0, 2% Tween 20	Cobi: 900 mL; Drv: 900 mL	Cobi: 5, 10, 15, 20 and 30; Drv: 10, 15, 20, 30 and 45	2016/10/20
Cobicistat/Elvitegravir/ Emtricitabine/Tenofovir Alafenamide Fumarate	Tablet	II (Paddle)	100	0.05 M sodium citrate buffer pH 5.5 containing 2.0% w/v polysorbate 80	1000	5, 10, 15, 20 and 30	2016/10/20
Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate	Tablet	II (Paddle) with sinker	100	0.01 N HCl with 2% w/w Polysorbate 80	1000	5, 10, 15, 20 and 30	2015/06/25
Cobimetinib Fumarate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Codeine Sulfate	Tablet			Refer to USP			2011/09/01
Colchicine	Capsule			Develop a dissolution method			2023/09/15
Colchicine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Colesevelam HCl	Tablet			Disintegration Testing as per USP <701> in various media such as simulated gastric fluid and simulated intestinal fluid.			2010/10/28
Crinecerfont	Capsule	I (Basket)	100	Tier 1 Medium: 0.6% SDS in 0.1 N HCl Tier 2 Medium: (first 12 min: 0.1 N HCl + pepsin 750,000 units/L), after 12 min add 100 mL of 5.5% SDS in 0.1 N HCl		15, 20, 30, 45 and 60	2026/01/28
Crizotinib	Capsule	I (Basket)	100	0.1N HCl (degassed)	900	5, 10, 15, 30 and 45	2016/04/14
Crofelemer	Tablet (Delayed Release)	II (Paddle)	75	Acid stage: 0.1 N HCl; Buffer stage: Sodium phosphate buffer, pH 6.8	Acid stage: 750; Buffer stage: 1000	Acid stage: 2 hours; Buffer stage: : 5, 10, 20, 30 and 45 minutes	2016/06/02
Cyclobenzaprine	Capsule (Extended Release)			Refer to USP			2016/10/20
Cyclobenzaprine HCl	Tablet			Refer to USP			2007/07/25
Cyclobenzaprine Hydrochloride	Tablet	II (Paddle)	50	50 mM Citrate Buffer, pH 4.0	100	5, 10, 15, 20, 30, 45 and 60	2026/03/25
Cyclophosphamide	Tablet			Develop a dissolution method			2023/09/15