美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Clonidine ( 0.1 mg)	Tablet (Extended Release)	II (Paddle) with sinker	50	Acid stage: 0.01 N HCl; Buffer stage: Phosphate Buffer, pH 7.0	Acid stage: 500; Buffer stage: 500	Acid stage: 1 and 2 hours; Buffer stage: 1, 2, 4, 6, 10, 14 and 16 hours	2012/01/26
Clonidine ( EQ. 0.17 mg and EQ. 0.26 mg)	Tablet (Extended Release)	II (Paddle)	50	500 mL 0.1N HCl for the 1st hour, then add 400 mL 0.27M Sodium Phosphate (Dibasic) buffer solution	Acid stage: 500; Buffer stage: 900	1, 2, 3, 6, 9, 12, 16, 20 and 24 hours	2010/07/01
Clonidine HCl	Tablet			Refer to USP			2007/06/18
Clonidine HCl (0.1 mg & 0.2 mg)	Tablet (Extended Release)	II (Paddle) with sinker	50	Acid stage: 0.01 N HCl; Buffer stage: Phosphate Buffer, pH 7.0	Acid stage: 500; Buffer stage: 500	Acid stage: 1 and 2 hours; Buffer stage: 1, 2, 4, 6, 10, 14 and 16 hours	2015/08/27
Clonidine Hydrochloride	Suspension, Extended Release	II (Paddle)	50	0.6 M KH2PO4 solution, pH 4.3	900	0.5, 1, 2, 3, 4, 6, 8, 12, 14, 16, 18 and 24 hours	2025/06/23
Clopidogrel Bisulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Clorazepate Dipotassium	Tablet			Refer to USP			2013/01/31
Clotrimazole	Lozenge			Refer to USP			2008/10/06
Clotrimazole	Tablet (Vaginal)	II (Paddle)	50	0.1 N HCl	900	10, 20, 30 and 45	2004/01/24
Clozapine	Tablet (Orally Disintegrating)	II (Paddle	50 RPM (12.5 mg, 25 mg and 100 mg); 75 RPM (150 mg and 200 mg)	pH 4.5 Acetate Buffer	900	5, 10, 15, 20, and 30	2011/06/09
Clozapine	Tablet			Refer to USP			2011/07/21
Clozapine	Suspension	II (Paddle)	50	Acetate Buffer (pH 4.0)	900	5, 10, 15, 20 and 30	2015/05/28
Cobicistat	Tablet	II (Paddle)	75	50 mM Sodium Acetate Buffer, pH 4.5	900	5, 10, 15, 20 and 30	2015/08/27
Cobicistat (Cobi)/ Darunavir Ethanolate (Drv)	Tablet	Cobi: II (Paddle): Drv: II (Paddle)	Cobi: 75; Drv:75	Cobi: 0.05 M Citrate Phosphate Buffer, pH 4.2; Drv: 0.05 M Sodium Phosphate Buffer, pH 3.0, 2% Tween 20	Cobi: 900 mL; Drv: 900 mL	Cobi: 5, 10, 15, 20 and 30; Drv: 10, 15, 20, 30 and 45	2016/10/20
Cobicistat/Elvitegravir/ Emtricitabine/Tenofovir Alafenamide Fumarate	Tablet	II (Paddle)	100	0.05 M sodium citrate buffer pH 5.5 containing 2.0% w/v polysorbate 80	1000	5, 10, 15, 20 and 30	2016/10/20
Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate	Tablet	II (Paddle) with sinker	100	0.01 N HCl with 2% w/w Polysorbate 80	1000	5, 10, 15, 20 and 30	2015/06/25
Cobimetinib Fumarate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Codeine Sulfate	Tablet			Refer to USP			2011/09/01
Colchicine	Capsule			Develop a dissolution method			2023/09/15
Colchicine	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02