美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Cholic Acid	Capsule	II (Paddle) with sinker	100	Phosphate Buffer, pH 6.8	500 mL for 50 mg capsule; 900 mL for 250 mg capsule	5, 10, 15, 20 and 30	2016/03/17
Choline Fenofibrate	Capsule (Delayed Release)	II (Paddle)	50	Acid Stage: 0.05M Sodium Phosphate, pH 3.5 ± 0.05; Buffer Stage: 0.05 M Sodium Phosphate, pH 6.8 ± 0.05	Acid stage: 500; Buffer stage: 900	Acid stage: 120; Buffer stage: 15, 30, 60, 90, 120, 240 and 360	2010/07/01
Ciclopirox	Topical Suspension			Develop a method to characterize in vitro release			2010/03/25
Cilostazol	Tablet			Develop a dissolution method			2023/09/15
Cimetidine	Tablet			Refer to USP			2023/11/30
Cinacalcet HCl	Tablet	II (Paddle)	75	0.05 N HCl	900	10, 20, 30 and 45	2006/01/26
Ciprofloxacin	Injectable Suspension [Otic]	IV (Flow through cell-closed loop) / 22 mm	Flow @ 6 mL/min	50 mM Acetate Buffer, pH 4.5 @37°C ± 0.5 [use glass beads; sample volume: 100 μl]	480	5, 10, 15, 20, 30, 45, 60 and 75	2016/03/17
Ciprofloxacin	Oral Suspension	II (Paddle)	100	0.05 M Acetate Buffer with 0.025% Brij35 (polyoxyethylene lauryl ether), pH 4.5	900	10, 20, 30 and 45	2010/03/25
Ciprofloxacin HCl	Tablet			Refer to USP			2010/09/02
Ciprofloxacin HCl	Tablet (Extended Release)	I (Basket)	100	0.1 N HCl	900	1, 2, 4, and 7 hours or until at least 80% released	2008/01/14
Ciprofloxacin HCl/Hydrocortisone	Otic Suspension			Develop a method to characterize in vitro release			2011/09/01
Ciprofloxacin/Ciprofloxacin HCl (AB)	Tablet (Extended Release)	II (Paddle)	50	0.1 N HCl	900	15, 30, 60, and 120	2008/01/14
Ciprofloxacin/Dexamethasone	Otic Suspension			Develop a method to characterize in vitro release			2016/03/17
Citalopram	Capsule			Refer to FDA's Dissolution Guidance, 2018			2023/07/07
Citalopram HBr	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Citalopram Hydrobromide	Capsule	II (Paddle)	50	0.1 N HCl	900	10, 20, 30 and 45	2008/10/06
Cladribine	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8 (deaerated)	900	5, 10, 15, 20 and 30	2022/05/12
Clarithromycin	Suspension	II (Paddle)	50	0.05 M Phosphate Buffer, pH 6.8	900	10, 20, 30, 45 and 60	2004/01/23
Clarithromycin	Tablet (Extended Release)			Refer to USP			2008/10/06
Clarithromycin	Tablet			Refer to USP			2007/07/25