美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Cetirizine	Capsule (Soft-Gelatin)	II (Paddle)	50	25 mM pH 6.8 phosphate buffer	900	5, 10, 15, 20, 30 and 45	2015/01/15
Cetirizine HCl	Tablet (Orally Disintegrating)			Refer to USP			2016/03/17
Cetirizine HCl	Tablet (Regular & Chewable)			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Cetirizine HCl/Pseudoephedrine HCl	Tablet (Extended Release)	I (Basket)	100	0.1 N HCl	500	0.17, 0.25, 0.5, 1, 2, 6 and 8 hours	2007/06/18
Cevimeline HCL	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Chlorambucil	Tablet	II (Paddle)	75	0.1 N HCl	900	10, 20, 30, and 45	2006/08/17
Chlordiazepoxide HCl/ Clidinium Bromide	Capsule			Develop a dissolution method			2024/01/03
Chlorhexidine Gluconate	Tablet (Dental)			Develop a method to characterize in vitro release			2022/07/07
Chloroquine Phosphate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/04/16
Chlorothiazide	Suspension			Develop a dissolution method			2019/03/07
Chlorpheniramine Maleate	Tablet (Extended Release)	III (Reciprocating Cylinder)	27 dpm	Row 1: Test Fluid 1 (0.1N HCl) for 1st hour. Row 2: Test fluid 2 (Phosphate Buffer, pH 7.5) for 5th hour	Row 1: 250 mL. Row 2: 250 mL	1 hour for test fluid 1, and 4 hours for test fluid 2	2007/07/25
Chlorpheniramine Maleate/Codeine Phosphate	Tablet (Extended Release)	II (Paddle)	50	Simulated gastric fluid (SGF) without enzyme (pH 1.2)	900	0.5, 1, 2, 4, 6, 8 and 12 hours	2016/10/20
Chlorpheniramine Maleate/Ibuprofen/Phenylephrine HCl	Tablet	II (Paddle)	50	50 mM Potassium Phosphate Buffer, pH 6.5 (degassed)	900	5, 10, 15, 20 and 30	2015/06/25
Chlorpheniramine Maleate/Ibuprofen/Pseudoephedrine HCl	Tablet	II (Paddle)	50	0.05 M Phosphate Buffer, pH 6.5	900	10, 20, 30 and 45	2004/02/20
Chlorpheniramine Polistirex/ Codeine polistirex	Suspension (Extended Release)	II (Paddle)	50	Acid Stage: 0.1 N HCl; Buffer Stage: pH 6.8 Phosphate Buffer [500 mL 0.1 N HCl for 1 hour, followed by addition of 400 mL of 0.2M NaH2P04 to pH 6.8]	Acid Stage: 500 mL; Buffer Stage: 900 mL	Acid Stage: 1 hour; Buffer Stage: 1, 2, 4, 6, 8 and 12 hours	2016/03/17
Chlorpheniramine Polistirex/Hydrocodone Polistirex	Extended Release Oral Suspension	II (Paddle)	50	Simulated Gastric Fluid (SGF) at 37ºC ± 0.5ºC	495	1, 2, 3, 6, 8, 12, 16 and 24 hours	2011/06/30
Chlorpheniramine Polistirex/Hydrocodone Polistirex	Capsule (Extended Release)	II (Paddle)	50	Simulated Intestinal Fluid without enzyme	500	1, 4, 12, and 24 hours	2008/11/25
Chlorpromazine HCl	Tablet			Refer to USP			2012/01/05
Chlorthalidone	Tablet			Develop a dissolution method			2024/01/03
Chlorzoxazone	Tablet			Develop a dissolution method			2024/01/03