美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Chloroquine Phosphate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/04/16
Chlorothiazide	Suspension			Develop a dissolution method			2019/03/07
Chlorpheniramine Maleate	Tablet (Extended Release)	III (Reciprocating Cylinder)	27 dpm	Row 1: Test Fluid 1 (0.1N HCl) for 1st hour. Row 2: Test fluid 2 (Phosphate Buffer, pH 7.5) for 5th hour	Row 1: 250 mL. Row 2: 250 mL	1 hour for test fluid 1, and 4 hours for test fluid 2	2007/07/25
Chlorpheniramine Maleate/Codeine Phosphate	Tablet (Extended Release)	II (Paddle)	50	Simulated gastric fluid (SGF) without enzyme (pH 1.2)	900	0.5, 1, 2, 4, 6, 8 and 12 hours	2016/10/20
Chlorpheniramine Maleate/Ibuprofen/Phenylephrine HCl	Tablet	II (Paddle)	50	50 mM Potassium Phosphate Buffer, pH 6.5 (degassed)	900	5, 10, 15, 20 and 30	2015/06/25
Chlorpheniramine Maleate/Ibuprofen/Pseudoephedrine HCl	Tablet	II (Paddle)	50	0.05 M Phosphate Buffer, pH 6.5	900	10, 20, 30 and 45	2004/02/20
Chlorpheniramine Polistirex/ Codeine polistirex	Suspension (Extended Release)	II (Paddle)	50	Acid Stage: 0.1 N HCl; Buffer Stage: pH 6.8 Phosphate Buffer [500 mL 0.1 N HCl for 1 hour, followed by addition of 400 mL of 0.2M NaH2P04 to pH 6.8]	Acid Stage: 500 mL; Buffer Stage: 900 mL	Acid Stage: 1 hour; Buffer Stage: 1, 2, 4, 6, 8 and 12 hours	2016/03/17
Chlorpheniramine Polistirex/Hydrocodone Polistirex	Extended Release Oral Suspension	II (Paddle)	50	Simulated Gastric Fluid (SGF) at 37ºC ± 0.5ºC	495	1, 2, 3, 6, 8, 12, 16 and 24 hours	2011/06/30
Chlorpheniramine Polistirex/Hydrocodone Polistirex	Capsule (Extended Release)	II (Paddle)	50	Simulated Intestinal Fluid without enzyme	500	1, 4, 12, and 24 hours	2008/11/25
Chlorpromazine HCl	Tablet			Refer to USP			2012/01/05
Chlorthalidone	Tablet			Develop a dissolution method			2024/01/03
Chlorzoxazone	Tablet			Develop a dissolution method			2024/01/03
Cholic Acid	Capsule	II (Paddle) with sinker	100	Phosphate Buffer, pH 6.8	500 mL for 50 mg capsule; 900 mL for 250 mg capsule	5, 10, 15, 20 and 30	2016/03/17
Choline Fenofibrate	Capsule (Delayed Release)	II (Paddle)	50	Acid Stage: 0.05M Sodium Phosphate, pH 3.5 ± 0.05; Buffer Stage: 0.05 M Sodium Phosphate, pH 6.8 ± 0.05	Acid stage: 500; Buffer stage: 900	Acid stage: 120; Buffer stage: 15, 30, 60, 90, 120, 240 and 360	2010/07/01
Ciclopirox	Topical Suspension			Develop a method to characterize in vitro release			2010/03/25
Cilostazol	Tablet			Develop a dissolution method			2023/09/15
Cimetidine	Tablet			Refer to USP			2023/11/30
Cinacalcet HCl	Tablet	II (Paddle)	75	0.05 N HCl	900	10, 20, 30 and 45	2006/01/26
Ciprofloxacin	Injectable Suspension [Otic]	IV (Flow through cell-closed loop) / 22 mm	Flow @ 6 mL/min	50 mM Acetate Buffer, pH 4.5 @37°C ± 0.5 [use glass beads; sample volume: 100 μl]	480	5, 10, 15, 20, 30, 45, 60 and 75	2016/03/17
Ciprofloxacin	Oral Suspension	II (Paddle)	100	0.05 M Acetate Buffer with 0.025% Brij35 (polyoxyethylene lauryl ether), pH 4.5	900	10, 20, 30 and 45	2010/03/25