美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Ceftibuten Dihydrate	Suspension	II (Paddle)	50	0.05 M Phosphate Buffer, pH 7.0	1000	10, 20, 30 and 45	2004/01/21
Cefuroxime Axetil	Tablet			Refer to USP			2007/07/25
Celecoxib	Capsule	II (Paddle)	50 mg, 100 mg and 200 mg: 50 rpm; 400 mg: 75 rpm	Tier 1 Medium: 0.04 M tribasic sodium phosphate (pH 12) with 1% SLS. Tier 2 Initial Medium: 750 mL of simulated gastric fluid, USP (includes pepsin); At 20 minutes, while stirring, add 180 mL of appropriate concentrations of SLS solution (for a final concentration of 1% SLS). Add about 70 mL of 1.2 N NaOH to adjust the pH to 12.	Tier 1: 1000 mL Tier 2: 750 mL (initial) 1000 mL (final)	10, 20, 30, 45 and 60	2010/07/01
Celecoxib; Tramadol HCl	Tablet	II (Paddle)	75	0.1N Hydrochloric Acid + 2% SLS	1000	5, 10, 15, 20, 30, 45 and 60	2023/07/07
Cenobamate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2024/08/05
Cephalexin	Suspension			Develop a dissolution method			2023/09/15
Cephalexin	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Ceritinib	Capsule	II (Paddle)	60	0.01 N HCl (degassed)	900	5, 10, 15, 20 and 30	2015/08/27
Ceritinib	Tablet	I (Basket)	75	0.01 N HCl (degassed)	900	5, 10, 15, 20 and 30	2021/04/22
Cetirizine	Capsule (Soft-Gelatin)	II (Paddle)	50	25 mM pH 6.8 phosphate buffer	900	5, 10, 15, 20, 30 and 45	2015/01/15
Cetirizine HCl	Tablet (Regular & Chewable)			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Cetirizine HCl	Tablet (Orally Disintegrating)			Refer to USP			2016/03/17
Cetirizine HCl/Pseudoephedrine HCl	Tablet (Extended Release)	I (Basket)	100	0.1 N HCl	500	0.17, 0.25, 0.5, 1, 2, 6 and 8 hours	2007/06/18
Cevimeline HCL	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Chlorambucil	Tablet	II (Paddle)	75	0.1 N HCl	900	10, 20, 30, and 45	2006/08/17
Chlordiazepoxide HCl/ Clidinium Bromide	Capsule			Develop a dissolution method			2024/01/03
Chlorhexidine Gluconate	Tablet (Dental)			Develop a method to characterize in vitro release			2022/07/07
Chloroquine Phosphate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/04/16
Chlorothiazide	Suspension			Develop a dissolution method			2019/03/07
Chlorpheniramine Maleate	Tablet (Extended Release)	III (Reciprocating Cylinder)	27 dpm	Row 1: Test Fluid 1 (0.1N HCl) for 1st hour. Row 2: Test fluid 2 (Phosphate Buffer, pH 7.5) for 5th hour	Row 1: 250 mL. Row 2: 250 mL	1 hour for test fluid 1, and 4 hours for test fluid 2	2007/07/25