美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Cefixime	Tablet (Chewable)	II (Paddle	25	Phosphate Buffer, pH 7.2	900	10, 15, 20, 30, and 45	2010/12/23
Cefixime	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Cefixime	Capsule	I (Basket)	100	0.05 M Phosphate Buffer, pH 7.2	900	10, 20, 30, 45 and 60	2013/08/15
Cefixime	Suspension	II (Paddle)	50	0.05 M Phosphate buffer, pH 7.2	900	10, 20, 30 and 45	2007/04/09
Cefpodoxime Proxetil	Tablet			Refer to USP			2007/07/25
Cefpodoxime Proxetil	Suspension	II (Paddle)	50	Glycine Buffer (0.04 M) pH 3.0	900	10, 20, 30 and 45	2005/12/20
Cefprozil	Tablet			Develop a dissolution method			2024/01/03
Cefprozil	For Oral Suspension			Develop a dissolution method			2023/09/15
Cefprozil Monohydrate	Suspension			Develop a dissolution method			2023/09/15
Ceftibuten Dihydrate	Suspension	II (Paddle)	50	0.05 M Phosphate Buffer, pH 7.0	1000	10, 20, 30 and 45	2004/01/21
Cefuroxime Axetil	Tablet			Refer to USP			2007/07/25
Celecoxib	Capsule	II (Paddle)	50 mg, 100 mg and 200 mg: 50 rpm; 400 mg: 75 rpm	Tier 1 Medium: 0.04 M tribasic sodium phosphate (pH 12) with 1% SLS. Tier 2 Initial Medium: 750 mL of simulated gastric fluid, USP (includes pepsin); At 20 minutes, while stirring, add 180 mL of appropriate concentrations of SLS solution (for a final concentration of 1% SLS). Add about 70 mL of 1.2 N NaOH to adjust the pH to 12.	Tier 1: 1000 mL Tier 2: 750 mL (initial) 1000 mL (final)	10, 20, 30, 45 and 60	2010/07/01
Celecoxib; Tramadol HCl	Tablet	II (Paddle)	75	0.1N Hydrochloric Acid + 2% SLS	1000	5, 10, 15, 20, 30, 45 and 60	2023/07/07
Celocoxib	Suspension	II (Paddle)	75	40 mM Sodium Phosphate Tribasic Buffer, pH 11.1 with 0.5% SDS	1000	5, 10, 15, 20, 30, 45 and 60	2026/03/25
Cenobamate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2024/08/05
Cephalexin	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Cephalexin	Tablet			Refer to FDA's Dissolution Guidance, 2018			2026/03/25
Cephalexin	Suspension			Develop a dissolution method			2023/09/15
Ceritinib	Tablet	I (Basket)	75	0.01 N HCl (degassed)	900	5, 10, 15, 20 and 30	2021/04/22
Ceritinib	Capsule	II (Paddle)	60	0.01 N HCl (degassed)	900	5, 10, 15, 20 and 30	2015/08/27