Efrotomycin
Structural Formula Vector Image
Title: Efrotomycin
CAS Registry Number: 56592-32-6
CAS Name: 31-O-[6-Deoxy-4-O-(6-deoxy-2,4-di-O-methyl-a-L-mannopyranosyl)-3-O-methyl-b-D-allopyranosyl]-1-methylmocimycin
Additional Names: 31-O-[6-deoxy-4-O-(6-deoxy-2,4-di-O-methylhexopyranosyl)-3-O-methylhexopyranosyl]-1-methylmocimycin
Manufacturers' Codes: FR-02A; MK-621
Trademarks: Producil (Merck & Co.)
Molecular Formula: C59H88N2O20
Molecular Weight: 1145.33
Percent Composition: C 61.87%, H 7.74%, N 2.45%, O 27.94%
Literature References: Antibiotic produced by Streptomyces lactamdurans NRRL 3802: R. G. Wax, W. M. Maiese, DE 2450813 (1975 to Merck & Co.), C.A. 83, 145755y (1975); R. G. Wax et al., J. Antibiot. 29, 670 (1976). In vitro and in vivo activity: B. M. Frost et al., ibid. 1083; 32, 626 (1979). Production and growth promoting activity: W. M. Maiese, R. G. Wax, US 4024251 (1977 to Merck & Co.). Synergism with bottromycin, q.v.: B. M. Frost et al., J. Antibiot. 32, 1046 (1979). Structure: R. S. Dewey et al., ibid. 38, 1691 (1985). Stereospecific total synthesis: R. E. Dolle, K. C. Nicolaou, J. Am. Chem. Soc. 107, 1691, 1695 (1985). HPLC determn in feeds: J. D. Strong, Analyst 111, 853 (1986). Effect on gain and feed efficiency in swine: A. G. Foster et al., J. Anim. Sci. 65, 877 (1987).
Properties: Pale yellow solid. uv max (pH 7): 232, 327 nm (E1%1cm 464, 216). LD50 in mice (g/kg): >4 orally; >2 s.c. (Frost).
Absorption maximum: uv max (pH 7): 232, 327 nm (E1%1cm 464, 216)
Toxicity data: LD50 in mice (g/kg): >4 orally; >2 s.c. (Frost)
Therap-Cat-Vet: Growth stimulant.

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