Structural Formula Vector Image
Title: Tryparsamide
CAS Registry Number: 554-72-3
CAS Name: [4-[(2-Amino-2-oxoethyl)amino]phenyl]arsonic acid monosodium salt
Additional Names: N-(carbamoylmethyl)arsanilic acid monosodium salt; monosodium N-phenylglycinamide-p-arsonate
Trademarks: Glyphenarsine; Tryparsone; Tryponarsyl; Trypothane
Molecular Formula: C8H10AsN2NaO4
Molecular Weight: 296.09
Percent Composition: C 32.45%, H 3.40%, As 25.30%, N 9.46%, Na 7.76%, O 21.61%
Literature References: Prepd by heating a soln of arsanilic acid in aq NaOH, Na2CO3 and chloroacetamide: Jacobs, Heidelberger, J. Am. Chem. Soc. 41, 1590 (1919); Org. Synth. 8, 100 (1928). US 1280119; US 1280124; US 1280126 (1918); US 2465308 (1949).
Derivative Type: Hemihydrate
Properties: Platelets, slowly affected by light, stable to air. One gram dissolves in about 2 ml water. Slightly sol in alcohol. Insol in ether, chloroform. pH of 1:20 aq soln 6.5. Keep tryparsamide in tight containers, preferably at a temp not above 20° and protected from light.
Therap-Cat: Antiprotozoal (Trypanosoma).
Keywords: Antiprotozoal (Trypanosoma).

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