Structural Formula Vector Image
Title: Trospectomycin
CAS Registry Number: 88669-04-9
CAS Name: (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-2-Butyldecahydro-4a,7,9-trihydroxy-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Additional Names: 6ยข-n-propylspectinomycin
Molecular Formula: C17H30N2O7
Molecular Weight: 374.43
Percent Composition: C 54.53%, H 8.08%, N 7.48%, O 29.91%
Literature References: Semi-synthetic analog of spectinomycin. Prepn: D. R. White, DE 3308196; idem, US 4532336 (1983, 1985 both to Upjohn); D. R. White et al., J. Antibiot. 36, 339 (1983); P. M. Herrinton et al., J. Org. Chem. 58, 678 (1993). In vitro activity: G. E. Zurenko et al., Antimicrob. Agents Chemother. 32, 216 (1988). Mode of action: E. M. Veringa et al., Int. J. Med. Microbiol. 271, 311 (1989). Pharmacokinetic and tolerance study: G. R. Peters et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 28, 361 (1990). HPLC determn in plasma and serum: R. J. Simmonds et al., J. Liq. Chromatogr. 13, 1125 (1990). Clinical study in gonorrhea: T. F. Mroczkowski et al., Drugs Exp. Clin. Res. 19, 41 (1993).
Derivative Type: Sulfate pentahydrate
CAS Registry Number: 88851-61-0
Manufacturers' Codes: U-63366F
Trademarks: Spexil
Molecular Formula: C17H30N2O7.H2SO4.5H2O
Molecular Weight: 562.58
Percent Composition: C 36.29%, H 7.52%, N 4.98%, O 45.50%, S 5.70%
Properties: Crystals from acetone/water.
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.
Status: This monograph has been retired and is no longer subject to revision or update.

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