Structural Formula Vector Image
Title: Sulfasomizole
CAS Registry Number: 632-00-8
CAS Name: 4-Amino-N-(3-methyl-5-isothiazolyl)benzenesulfonamide
Additional Names: 3-methyl-5-sulfanilamidoisothiazole; 5-p-aminobenzenesulfonamido-3-methylisothiazole; 5-sulfanilamido-3-methylisothiazole; N1-(3-methylisothiazol-5-yl)sulfanilamide; sulphasomizole
Trademarks: Bidizole; Amidozol
Molecular Formula: C10H11N3O2S2
Molecular Weight: 269.34
Percent Composition: C 44.59%, H 4.12%, N 15.60%, O 11.88%, S 23.81%
Literature References: Preparation from N-acetylsulfanilyl chloride and 5-amino-3-methylisothiazole in pyridine followed by deacetylation in 2N NaOH: Adams, Slack, J. Chem. Soc. 1959, 3070; Adams et al., Nature 186, 221 (1960); GB 835753 (1960 to May & Baker).
Properties: Cream-colored needles from H2O, mp 192-192.5°. Soly in H2O at pH 6.0: 248 mg/100 ml; at pH 7.0: 2.26 g/100 ml.
Melting point: mp 192-192.5°
Derivative Type: Sodium salt monohydrate
Molecular Formula: C10H10N3NaO2S2.H2O
Molecular Weight: 309.34
Percent Composition: C 38.83%, H 3.91%, N 13.58%, Na 7.43%, O 15.52%, S 20.73%
Properties: Crystals, when anhydr dec 345°. Freely sol in water. Aq solns of almost neutral pH contg more than 50% w/v of the sodium salt can be made.
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.
Status: This monograph has been retired and is no longer subject to revision or update.

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