Sodium Ferric Gluconate
Structural Formula Vector Image
Title: Sodium Ferric Gluconate
CAS Registry Number: 34089-81-1
CAS Name: D-Gluconic acid iron(3+) sodium salt
Literature References: Bioavailable iron supplement containing a ferric hydroxide core stabilized and solubilized by simple carbohydrates. Prepn: W. Traube et al., Ber. 66B, 1545 (1933). Intestinal absorption of clinical formulations: L. Samochowiec, Clin. Ter. 56, 341 (1971).
Derivative Type: Sodium ferric gluconate complex
Trademarks: Ferlixit (Aventis); Ferrlecit (Watson); Ferrosprint (Pfizer); Sanifer (Esseti)
Literature References: Aqueous iron formulation administered as an injectable, stable, macromolecular iron saccharate complex. Gluconate bridges the iron centers. Mol formula is approximately: [NaFe2O3(C6H11O7)(C12H22O11)5]n. Apparent mol wt 289-440 kDa. Safety profile: G. Faich, J. Strobos, Am. J. Kidney Dis. 33, 464 (1999). Clinical evaluation in hemodialysis patients: A. R. Nissenson et al., ibid. 471; and comparison with iron dextran: B. Michael et al., Kidney Int. 61, 1830 (2002). Clinical pharmacokinetics: P. A. Seligman et al., Pharmacotherapy 24, 574 (2004). Clinical evaluation in renal transplant patients: R. S. Gillespie, J. M. Symons, Pediatr. Transplant. 9, 43 (2005). Review of therapeutic applications: S. Fishbane, J. Wagner, Am. J. Kidney Dis. 37, 879-883 (2001).
Properties: Deep red color indicative of ferric oxide linkages.
Therap-Cat: Hematinic.
Keywords: Hematinic.

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