Structural Formula Vector Image
Title: Policosanol
CAS Registry Number: 142583-61-7
Additional Names: Sugar cane wax alcohols
Trademarks: Ateromixol (Dalmer); Lipex (Elea); Mercol (Exakta); Phytocor (Pharma Dynamics); PPG (Bago)
Literature References: Mixture of higher (C24 to C34) primary aliphatic alcohols purified from wax of sugar cane, Saccharum officinarum L., Gramineae. Composed of octacosanol (60-70%), triacontanol (10-15%), dotriacontanol (5-10%), hexacosanol (3-8%), heptacosanol, nonacosanol, tetratriacontanol, and tetracosanol. Prepn: L. Granja et al., WO 9407830; eidem, US 5856316 (1994, 1999 both to Dalmar). Clinical pharmacology: I. Gouni-Berthold, H. K. Berthold, Am. Heart J. 143, 356 (2002). Antiplatelet effects: M. L. Arruzazabala et al., Clin. Exp. Pharmacol. Physiol. 29, 891 (2002). Review of clinical studies: M. Janikula, Altern. Med. Rev. 7, 203-217 (2002); and comparison with plant sterols and stanols: J. T. Chen et al., Pharmacotherapy 25, 171-183 (2005).
Properties: Off-white, odorless crystalline powder. mp 78-82°. Insol in water, hexane, methanol, ethanol. Slightly sol in chloroform.
Melting point: mp 78-82°
Therap-Cat: Antilipemic.
Keywords: Antilipemic.

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