Haloprogin
Structural Formula Vector Image
Title: Haloprogin
CAS Registry Number: 777-11-7
CAS Name: 1,2,4-Trichloro-5-[(3-iodo-2-propynyl)oxy]benzene
Additional Names: 3-iodo-2-propynyl 2,4,5-trichlorophenyl ether; 2,4,5-trichlorophenyl g-iodopropargyl ether
Manufacturers' Codes: M-1028
Trademarks: Halotex (BMS); Mycanden (Schering AG)
Molecular Formula: C9H4Cl3IO
Molecular Weight: 361.39
Percent Composition: C 29.91%, H 1.12%, Cl 29.43%, I 35.12%, O 4.43%
Literature References: Prepn: S. Seki et al., Agric. Biol. Chem. 27, 150 (1963), C.A. 58, 14635g (1963); eidem, JP 64 19791; eidem, US 3322813 (1964, 1967 both to Meiji Seika). Pharmacology: S. Seki et al., Antimicrob. Agents Chemother. 1963, 569; E. F. Harrison et al., Appl. Microbiol. 19, 746 (1970).
Properties: White or pale yellow crystals, mp 113-114°; dec 190°. uv max (anhydr ethanol): 288.5, 298.5 nm. Easily soluble in methanol, ethanol; very slightly sol in water. LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963).
Melting point: mp 113-114°
Absorption maximum: uv max (anhydr ethanol): 288.5, 298.5 nm
Toxicity data: LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic).

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