Phenethyl Alcohol
Structural Formula Vector Image
Title: Phenethyl Alcohol
CAS Registry Number: 60-12-8
CAS Name: Benzeneethanol
Additional Names: 2-phenylethanol; b-phenylethyl alcohol; benzyl carbinol; b-hydroxyethylbenzene
Molecular Formula: C8H10O
Molecular Weight: 122.16
Percent Composition: C 78.66%, H 8.25%, O 13.10%
Literature References: Found in a number of natural essential oils, such as rose, carnation, hyacinth, Aleppo pine, orange blossom, geranium Bourbon, neroli and in the essential oil of champaca. Prepd by reduction of ethyl phenylacetate with sodium in abs alcohol: Bouveault, Blanc, Bull. Soc. Chim. [3] 31, 672 (1904); Leonard, J. Am. Chem. Soc. 47, 1778 (1925); by hydrogenation of phenylacetaldehyde in the presence of nickel catalyst: Skita, Ritter, Ber. 43, 3398 (1910); v. Braun, Kochendörfer, Ber. 56, 2176 (1923); Milligan, Reid, J. Am. Chem. Soc. 44, 204 (1922). Isoln from the fungus Gibberella fujikuroi: Cross et al., J. Chem. Soc. 1963, 2937. Antibacterial activity: R. M. E. Richards et al., J. Pharm. Pharmacol. 21, 681 (1969). Use as preservative in ophthalmic solutions: R. M. E. Richards, R. J. McBride, ibid. 24, 145 (1972). Toxicity: Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).
Properties: Liquid. Floral odor, rose character. mp -27°. d2525 1.017 to 1.019. bp750 219-221°; bp14 104°; bp12 98-100°. nD20 1.530 to 1.533. Two ml dissolve in 100 ml water after thorough shaking. One part is clearly sol in 1 part of 50% alc. Miscible with alcohol, ether. LD50 orally in rats: 1790 mg/kg (Jenner).
Melting point: mp -27°
Boiling point: bp750 219-221°; bp14 104°; bp12 98-100°
Index of refraction: nD20 1.530 to 1.533
Density: d2525 1.017 to 1.019
Toxicity data: LD50 orally in rats: 1790 mg/kg (Jenner)
Use: Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).

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