Structural Formula Vector Image
Title: Ciafos
CAS Registry Number: 2636-26-2
CAS Name: Phosphorothioic acid O-(4-cyanophenyl) O,O-dimethyl ester
Additional Names: phosphorothioic acid O,O-dimethyl ester, O-ester with p-hydroxybenzonitrile; O,O-dimethyl O-(4-cyanophenyl) phosphorothioate; O,O-dimethyl O-(4-cyanophenyl) thionophosphate; cyanophos
Manufacturers' Codes: Bay 34727; S-4084; Sumitomo S-4084
Trademarks: Cyanox (Sumitomo)
Molecular Formula: C9H10NO3PS
Molecular Weight: 243.22
Percent Composition: C 44.44%, H 4.14%, N 5.76%, O 19.73%, P 12.73%, S 13.18%
Literature References: Prepn: Nishizawa, Mizutani, JP 62 18184; Kuramoto et al., US 3150040 (1962, 1964 both to Sumitomo); Sakamoto, Nishizawa, Agric. Biol. Chem. 26, 252 (1962); D. N. Bernhart, DE 2162344; idem, US 3792132 (1972, 1974 to Stauffer). Pharmacology and metabolism: H. Yamamoto et al., Oyo Yakuri 5, 75 (1971), C.A. 76, 68907a (1972); Wakimura, Miyamoto, Agric. Biol. Chem. 35, 410 (1971). Evaluation as an insecticide: Nishiyawa et al., ibid. 25, 597 (1961); Tamura et al., ibid. 773. Evaluation of neurotoxicity: H. Ohkawa et al., Biochem. Pharmacol. 29, 2721 (1980).
Properties: Yellow to reddish-yellow transparent liquid. bp0.09 119-120° (dec). mp 14-15°. nD32.5 1.5404. Very sol in methanol, ethanol, acetone, chloroform. Sparingly sol in n-hexane, kerosene; slightly sol in water. Rapidly dec under alkaline conditions and upon exposure to light, Jpn. Med. Gaz. 11(7), 7 (1974). LD50 in mice (mg/kg): 1000 orally; 880 i.p. (Yamamoto).
Melting point: mp 14-15°
Boiling point: bp0.09 119-120° (dec)
Index of refraction: nD32.5 1.5404
Toxicity data: LD50 in mice (mg/kg): 1000 orally; 880 i.p. (Yamamoto)
CAUTION: Cholinesterase inhibitor.
Use: Insecticide.

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