Structural Formula Vector Image
Title: Pexiganan
CAS Registry Number: 147664-63-9
Additional Names: 7-L-Lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide magainin I
Molecular Formula: C122H210N32O22
Molecular Weight: 2477.17
Percent Composition: C 59.15%, H 8.54%, N 18.09%, O 14.21%
Literature References: Synthetic, 22 amino acid peptide; analog of the magainins, q.v. Prepn: B. Berkowitz, L. Jacob, WO 9301723 (1993 to Magainin). In vitro antibacterial spectrum: Y. Ge et al., Diagn. Microbiol. Infect. Dis. 35, 45 (1999). Review of development: L. Jacob, M. Zasloff, Ciba Found. Symp. 186, 197-216 (1994); of structure-activity studies: W. L. Maloy, U. P. Kari, Biopolymers 37, 105-122 (1995); of pharmacology and clinical trials in diabetic foot ulcers: H. M. Lamb, L. R. Wiseman, Drugs 56, 1047-1052 (1998).
Derivative Type: Acetate
CAS Registry Number: 172820-23-4
Manufacturers' Codes: MSI-78
Trademarks: Locilex (Magainin)
Line Formula: C122H210N32O22.xC2H4O2
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic).

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