Structural Formula Vector Image
Title: Parbendazole
CAS Registry Number: 14255-87-9
CAS Name: (5-Butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester
Additional Names: methyl 5-butyl-2-benzimidazolecarbamate; 5-butyl-2-(carbomethoxyamino)benzimidazole
Manufacturers' Codes: SKF-29044
Trademarks: Helmatac (SK & F); Verminum (Squibb); Worm Guard (SK & F)
Molecular Formula: C13H17N3O2
Molecular Weight: 247.29
Percent Composition: C 63.14%, H 6.93%, N 16.99%, O 12.94%
Literature References: Prepd from 4-butyl-o-phenylenediamine and carbomethoxycyanamide: Actor et al., Nature 215, 321 (1967); GB 1123317 and Stedman; Actor, Pagano, US 3480642; US 3574845 (1968, 1969, 1971 all to SKF). Activity: Ostmann, Scheidy, Prog. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. 1, 159 (1970). Identification of metabolites: Dunn et al., J. Med. Chem. 16, 996 (1973).
Properties: Crystals from aq ethanol, mp 225-227° (dec). uv max (95% ethanol/1N HCl): 282, 288 nm (e 16200, 20000). Practically insol in water. LD50 in mice, rats (g/kg): >4 orally, both species (Actor).
Melting point: mp 225-227° (dec)
Absorption maximum: uv max (95% ethanol/1N HCl): 282, 288 nm (e 16200, 20000)
Toxicity data: LD50 in mice, rats (g/kg): >4 orally, both species (Actor)
Therap-Cat-Vet: Anthelmintic.

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