Structural Formula Vector Image
Title: Nitrefazole
CAS Registry Number: 21721-92-6
CAS Name: 2-Methyl-4-nitro-1-(4-nitrophenyl)-1H-imidazole
Additional Names: 1-(4-nitrophenyl)-2-methyl-4-nitroimidazole
Manufacturers' Codes: EMD-15700
Trademarks: Altimol (Merck KGaA)
Molecular Formula: C10H8N4O4
Molecular Weight: 248.19
Percent Composition: C 48.39%, H 3.25%, N 22.57%, O 25.79%
Literature References: Aldehyde dehydrogenase inhibitor. Prepn: R. Klink, L. Hepding, GB 1133408; eidem, US 3491105 (1968, 1970 to E. Merck). Use as alcohol deterrent: A. Behpour et al., DE 2645709; eidem, US 4182770 (1978, 1980 to E. Merck). Effect on enzyme activity: C. A. Seyfried et al., Alcohol. Clin. Exp. Res. 6, 313 (1982). Effect on ethanol consumption: D. E. McMillan, Drug Dev. Res. 3, 193 (1983). Clinical studies: R. Dusing et al., Arzneim.-Forsch. 32, 903 (1982); D. Roscher, W. Poser, ibid. 905.
Properties: Crystals from acetone, mp 185-187°.
Melting point: mp 185-187°
Therap-Cat: Alcohol deterrent.
Keywords: Alcohol Deterrent.
Status: This monograph has been retired and is no longer subject to revision or update.

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