Structural Formula Vector Image
Title: Nadoxolol
CAS Registry Number: 54063-51-3
CAS Name: N,3-Dihydroxy-4-(1-naphthalenyloxy)butanimidamide
Additional Names: 3-hydroxy-4-(1-naphthyloxy)butyramidoxime; 4-(a-naphthyloxy)-3-hydroxybutyramidoxime
Molecular Formula: C14H16N2O3
Molecular Weight: 260.29
Percent Composition: C 64.60%, H 6.20%, N 10.76%, O 18.44%
Literature References: b-Adrenergic blocker. Prepn: Lafon, DE 2132113 corresp to US 3819702 (1972, 1974 to Orsymonde). Pharmacology: Duteil et al., Therapie 28, 703 (1973). Clinical studies: Tricot et al., ibid. 721.
Derivative Type: Hydrochloride
CAS Registry Number: 35991-93-6
Manufacturers' Codes: LL-1530
Trademarks: Bradyl (Lafon)
Molecular Formula: C14H16N2O3.HCl
Molecular Weight: 296.75
Percent Composition: C 56.66%, H 5.77%, N 9.44%, O 16.17%, Cl 11.95%
Properties: White crystalline powder from ethyl ether-methanol, mp 188°. Sol in water, methanol, ethanol. Insol in ethyl ether. LD50 in mice (mg/kg): 180 i.v.; 1000 orally (Lafon).
Melting point: mp 188°
Toxicity data: LD50 in mice (mg/kg): 180 i.v.; 1000 orally (Lafon)
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic.

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