Methacholine Chloride
Structural Formula Vector Image
Title: Methacholine Chloride
CAS Registry Number: 62-51-1
CAS Name: 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium chloride
Additional Names: acetyl-b-methylcholine chloride; O-acetyl-b-methylcholine chloride; (2-hydroxypropyl)trimethylammonium chloride acetate; (2-acetoxypropyl)trimethylammonium chloride; trimethyl-b-acetoxypropylammonium chloride
Trademarks: Amechol (Moorsfields); Provocholine (Roche)
Molecular Formula: C8H18ClNO2
Molecular Weight: 195.69
Percent Composition: C 49.10%, H 9.27%, Cl 18.12%, N 7.16%, O 16.35%
Literature References: Parasympathomimetic bronchoconstrictor. Prepn: R. T. Major, J. K. Cline, US 2040146 (1936 to Merck & Co.). Mechanism of ganglionic blockade in cats: R. L. Volle, J. Pharmacol. Exp. Ther. 158, 66 (1967). Clinical diagnostic efficacy in bronchial asthma: S. L. Spector, R. S. Farr, J. Allergy Clin. Immunol. 56, 308 (1975); J. G. Easton, I. Hirata, Ann. Allergy 50, 171 (1983).
Properties: White, hygroscopic needles from ether, mp 172-173°. Slight odor of dead fish. Freely sol in water, alcohol, chloroform. Insol in ether. Aq solns are neutral to litmus. Should not be handled in very moist atmosphere. Bromide is less hygroscopic.
Melting point: mp 172-173°
NOTE: Antidote: Atropine.
Therap-Cat: Cholinergic. Diagnostic aid (bronchial asthma).
Keywords: Cholinergic; Diagnostic Aid.

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