Lucanthone Hydrochloride
Structural Formula Vector Image
Title: Lucanthone Hydrochloride
CAS Registry Number: 548-57-2
CAS Name: 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one hydrochloride
Additional Names: 1-(2-diethylaminoethylamino)-4-methylthiaxanthone hydrochloride
Manufacturers' Codes: MS-752; RP-3735
Trademarks: Miracil D; Nilodin; Miracol; Tixantone
Molecular Formula: C20H25ClN2OS
Molecular Weight: 376.94
Percent Composition: C 63.73%, H 6.69%, Cl 9.41%, N 7.43%, O 4.24%, S 8.51%
Literature References: Prepd by the reaction of 1-chloro-4-methylthiaxanthone with asym-diethylethylenediamine: Mauss, Naturwissenschaften 33, 253 (1946); idem, Ber. 81, 19 (1948); Sharp, J. Chem. Soc. 1951, 2961; Archer, Suter, J. Am. Chem. Soc. 74, 4296 (1952). Review of mode of action: Weinstein, Hirschberg, Prog. Mol. Subcell. Biol. 2, 232 (1971). Review: Hirschberg in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 274-303.
Properties: Yellow crystals from alcohol, mp 195-196°. Freely sol in water. Aq soln (orange) is neutral. Slightly sol in alcohol.
Melting point: mp 195-196°
Derivative Type: Free base
Properties: mp 64-65°. Sol in the usual organic solvents.
Melting point: mp 64-65°
Therap-Cat: Anthelmintic (Schistosoma).
Keywords: Anthelmintic (Schistosoma).

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