Lamifiban
Structural Formula Vector Image
Title: Lamifiban
CAS Registry Number: 144412-49-7
CAS Name: (S)-[[1-[2-[[4-(Aminoiminomethyl)benzoyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-4-piperidinyl]oxy]acetic acid
Additional Names: [[1-[N-(p-amidinobenzoyl)-L-tyrosyl]-4-piperidinyl]oxy]acetic acid
Manufacturers' Codes: Ro-44-9883
Molecular Formula: C24H28N4O6
Molecular Weight: 468.50
Percent Composition: C 61.53%, H 6.02%, N 11.96%, O 20.49%
Literature References: Specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Prepn: L. Alig et al., EP 505868; eidem, US 5378712 (1992, 1995 both to Hoffmann-La Roche); L. Alig et al., J. Med. Chem. 35, 4393 (1992). Pharmacology: J.-P. Carteaux et al., Thromb. Haemostasis 70, 817 (1993); Y. Takiguchi et al., ibid. 73, 683 (1995).
Properties: Crystals (zwitterionic form) from water, mp above 200° (dec). [a]D20 +29.8° (c = 0.86 in 1N HCl).
Melting point: mp above 200° (dec)
Optical Rotation: [a]D20 +29.8° (c = 0.86 in 1N HCl)
 
Derivative Type: Trifluoroacetate salt
CAS Registry Number: 144412-50-0
Molecular Formula: C24H28N4O6.C2HF3O2
Molecular Weight: 582.53
Percent Composition: C 53.61%, H 5.02%, N 9.62%, O 21.97%, F 9.78%
Properties: mp 125-130° (dec). LD50 i.v. in mice: 250 mg/kg (Alig, 1995).
Melting point: mp 125-130° (dec)
Toxicity data: LD50 i.v. in mice: 250 mg/kg (Alig, 1995)
 
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Fibrinogen Receptor Antagonist.

Other Monographs:
N-(4-Aminobenzoyl)-L-glutamic acid1-NaphthylamineCalcium IodobehenateLead Borate
Abetimus SodiumAstacinLH-RHCRP
LivetinsEthyl SilicateTetracaine Hydrochloride2,6-Dinitroaniline
Ricinoleic AcidDideoxyadenosineSabadineAvoparcin
©2006-2023 DrugFuture->Chemical Index Database